The beneficial effect of acute exercise on motor memory consolidation is modulated by dopaminergic gene profile
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The beneficial effect of acute exercise on motor memory consolidation is modulated by dopaminergic gene profile. / Christiansen, Lasse; Thomas, Richard; Beck, Mikkel Malling; Pingel, Jessica; Andersen, Jeppe Dyrberg; Mang, Cameron S; Madsen, Mads Alexander Just; Roig, Marc; Lundbye-Jensen, Jesper.
In: Journal of Clinical Medicine, Vol. 8, No. 5, 578, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The beneficial effect of acute exercise on motor memory consolidation is modulated by dopaminergic gene profile
AU - Christiansen, Lasse
AU - Thomas, Richard
AU - Beck, Mikkel Malling
AU - Pingel, Jessica
AU - Andersen, Jeppe Dyrberg
AU - Mang, Cameron S
AU - Madsen, Mads Alexander Just
AU - Roig, Marc
AU - Lundbye-Jensen, Jesper
N1 - CURIS 2019 NEXS 149
PY - 2019
Y1 - 2019
N2 - When aerobic exercise is performed following skilled motor practice, it can enhance motor memory consolidation. Previous studies have suggested that dopamine may play a role in motor memory consolidation, but whether it is involved in the exercise effects on consolidation is unknown. Hence, we aimed to investigate the influence of dopaminergic pathways on the exercise-induced modulation of motor memory consolidation. We compared the effect of acute exercise on motor memory consolidation between the genotypes that are known to affect dopaminergic transmission and learning. By combining cluster analyses and fitting linear models with and without included polymorphisms, we provide preliminary evidence that exercise benefits the carriers of alleles that are associated with low synaptic dopamine content. In line with previous reports, our findings implicate dopamine as a modulator of the exercise-induced effects on motor memory consolidation, and suggest exercise as a potential clinical tool to counteract low endogenous dopamine bioavailability. Further experiments are needed to establish causal relations.
AB - When aerobic exercise is performed following skilled motor practice, it can enhance motor memory consolidation. Previous studies have suggested that dopamine may play a role in motor memory consolidation, but whether it is involved in the exercise effects on consolidation is unknown. Hence, we aimed to investigate the influence of dopaminergic pathways on the exercise-induced modulation of motor memory consolidation. We compared the effect of acute exercise on motor memory consolidation between the genotypes that are known to affect dopaminergic transmission and learning. By combining cluster analyses and fitting linear models with and without included polymorphisms, we provide preliminary evidence that exercise benefits the carriers of alleles that are associated with low synaptic dopamine content. In line with previous reports, our findings implicate dopamine as a modulator of the exercise-induced effects on motor memory consolidation, and suggest exercise as a potential clinical tool to counteract low endogenous dopamine bioavailability. Further experiments are needed to establish causal relations.
KW - Faculty of Science
KW - Physical activity
KW - Consolidation
KW - Dopamine
KW - Genetics
KW - Motor learning
KW - Single-nucleotide polymorphisms
KW - Dopamine receptor
U2 - 10.3390/jcm8050578
DO - 10.3390/jcm8050578
M3 - Journal article
C2 - 31035583
VL - 8
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
SN - 2077-0383
IS - 5
M1 - 578
ER -
ID: 217379600