The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin.
Research output: Contribution to journal › Journal article › Research › peer-review
Fibroblasts migrating from heart explants of chick embryos at first have a high rate of locomotion but lack focal contacts or adhesions and also lack substantial actin-containing bundles. A meshwork of 7-nm filaments is present particularly in submembranous regions and is proposed to be directed towards efficient locomotion whilst maintaining a high degree of spreading. Also during the first 48 h there is little production of extracellular fibronectin and the growth rate is low. Later, these fibroblasts develop focal contacts and focal adhesions together with actomyosin bundles, with a parallel increase in fibronectin expression. We propose that progressive immobilization by the development of focal adhesions and actomyosin structures occurs to set these cells up for growth.
Original language | English |
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Journal | Journal of Cell Science |
Volume | 39 |
Pages (from-to) | 149-65 |
Number of pages | 16 |
ISSN | 0021-9533 |
Publication status | Published - 1979 |
Bibliographical note
Keywords: Actomyosin; Animals; Cell Adhesion; Cell Cycle; Cell Division; Cell Membrane; Cell Movement; Chick Embryo; Cytoskeleton; Fibroblasts; Fibronectins; Myocardium
ID: 5167990