Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd)

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A series of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd) and its uracil analog (EUrd) have been synthesized. While none of the conformationally restricted analogs displayed anticancer activity, 5-iodo-EUrd and 5-bromo-EUrd displayed potent anticancer activity with IC50 values of 35 nM and 0. 73 microM.
Original languageEnglish
JournalNucleosides, nucleotides & nucleic acids
Volume24
Issue number5-7
Pages (from-to)397-400
Number of pages4
ISSN1525-7770
Publication statusPublished - 2005
Externally publishedYes

    Research areas

  • Antimetabolites, Antineoplastic Agents, Cell Line, Tumor, Chemistry, Pharmaceutical, Cytidine, Drug Design, Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Models, Chemical, Neoplasms, Nucleic Acid Conformation, Uracil, Uridine

ID: 59322958