Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd)
Research output: Contribution to journal › Journal article › peer-review
A series of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd) and its uracil analog (EUrd) have been synthesized. While none of the conformationally restricted analogs displayed anticancer activity, 5-iodo-EUrd and 5-bromo-EUrd displayed potent anticancer activity with IC50 values of 35 nM and 0. 73 microM.
Original language | English |
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Journal | Nucleosides, nucleotides & nucleic acids |
Volume | 24 |
Issue number | 5-7 |
Pages (from-to) | 397-400 |
Number of pages | 4 |
ISSN | 1525-7770 |
Publication status | Published - 2005 |
Externally published | Yes |
- Antimetabolites, Antineoplastic Agents, Cell Line, Tumor, Chemistry, Pharmaceutical, Cytidine, Drug Design, Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Models, Chemical, Neoplasms, Nucleic Acid Conformation, Uracil, Uridine
Research areas
ID: 59322958