Stable markers of oxidant damage to proteins and their application in the study of human disease

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Stable markers of oxidant damage to proteins and their application in the study of human disease. / Davies, Michael Jonathan; Fu, S; Wang, H; Dean, R T.

In: Free Radical Biology & Medicine, Vol. 27, No. 11-12, 12.1999, p. 1151-63.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Davies, MJ, Fu, S, Wang, H & Dean, RT 1999, 'Stable markers of oxidant damage to proteins and their application in the study of human disease', Free Radical Biology & Medicine, vol. 27, no. 11-12, pp. 1151-63.

APA

Davies, M. J., Fu, S., Wang, H., & Dean, R. T. (1999). Stable markers of oxidant damage to proteins and their application in the study of human disease. Free Radical Biology & Medicine, 27(11-12), 1151-63.

Vancouver

Davies MJ, Fu S, Wang H, Dean RT. Stable markers of oxidant damage to proteins and their application in the study of human disease. Free Radical Biology & Medicine. 1999 Dec;27(11-12):1151-63.

Author

Davies, Michael Jonathan ; Fu, S ; Wang, H ; Dean, R T. / Stable markers of oxidant damage to proteins and their application in the study of human disease. In: Free Radical Biology & Medicine. 1999 ; Vol. 27, No. 11-12. pp. 1151-63.

Bibtex

@article{a25a61fd0ec44bfda7965f1208e76952,
title = "Stable markers of oxidant damage to proteins and their application in the study of human disease",
abstract = "The mechanisms of formation and the nature of the altered amino acid side chains formed on proteins subjected to oxidant attack are reviewed. The use of stable products of protein side chain oxidation as potential markers for assessing oxidative damage in vivo in humans is discussed. The methods developed in the authors laboratories are outlined, and the advantages and disadvantages of these techniques compared with other methodologies for assessing oxidative damage to proteins and other macromolecules. Evidence is presented to show that protein oxidation products are sensitive markers of oxidative damage, that the pattern of products detected may yield information as to the nature of the original oxidative insult, and that the levels of oxidized side-chains can, in certain circumstances, be much higher than those of other markers of oxidation such as lipid hydroperoxides.",
keywords = "Amino Acids, Animals, Biological Markers, Disease, Humans, Oxidants, Oxidation-Reduction, Oxidative Stress, Proteins",
author = "Davies, {Michael Jonathan} and S Fu and H Wang and Dean, {R T}",
year = "1999",
month = dec,
language = "English",
volume = "27",
pages = "1151--63",
journal = "Free Radical Biology & Medicine",
issn = "0891-5849",
publisher = "Elsevier",
number = "11-12",

}

RIS

TY - JOUR

T1 - Stable markers of oxidant damage to proteins and their application in the study of human disease

AU - Davies, Michael Jonathan

AU - Fu, S

AU - Wang, H

AU - Dean, R T

PY - 1999/12

Y1 - 1999/12

N2 - The mechanisms of formation and the nature of the altered amino acid side chains formed on proteins subjected to oxidant attack are reviewed. The use of stable products of protein side chain oxidation as potential markers for assessing oxidative damage in vivo in humans is discussed. The methods developed in the authors laboratories are outlined, and the advantages and disadvantages of these techniques compared with other methodologies for assessing oxidative damage to proteins and other macromolecules. Evidence is presented to show that protein oxidation products are sensitive markers of oxidative damage, that the pattern of products detected may yield information as to the nature of the original oxidative insult, and that the levels of oxidized side-chains can, in certain circumstances, be much higher than those of other markers of oxidation such as lipid hydroperoxides.

AB - The mechanisms of formation and the nature of the altered amino acid side chains formed on proteins subjected to oxidant attack are reviewed. The use of stable products of protein side chain oxidation as potential markers for assessing oxidative damage in vivo in humans is discussed. The methods developed in the authors laboratories are outlined, and the advantages and disadvantages of these techniques compared with other methodologies for assessing oxidative damage to proteins and other macromolecules. Evidence is presented to show that protein oxidation products are sensitive markers of oxidative damage, that the pattern of products detected may yield information as to the nature of the original oxidative insult, and that the levels of oxidized side-chains can, in certain circumstances, be much higher than those of other markers of oxidation such as lipid hydroperoxides.

KW - Amino Acids

KW - Animals

KW - Biological Markers

KW - Disease

KW - Humans

KW - Oxidants

KW - Oxidation-Reduction

KW - Oxidative Stress

KW - Proteins

M3 - Journal article

C2 - 10641706

VL - 27

SP - 1151

EP - 1163

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

SN - 0891-5849

IS - 11-12

ER -

ID: 138282023