Solid-state interactions between trimethoprim and parabens
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Solid-state interactions between trimethoprim and parabens. / Pedersen, S.; Kristensen, H. G.; Cornett, Claus.
In: STP pharma sciences, Vol. 4, No. 4, 1994, p. 292-297.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Solid-state interactions between trimethoprim and parabens
AU - Pedersen, S.
AU - Kristensen, H. G.
AU - Cornett, Claus
PY - 1994
Y1 - 1994
N2 - Solid-state interactions between trimethoprim and the esters of 4-hydroxybenzoic acid (parahydroxybenzoates or parabens) used for anti-microbial preservation are investigated. The formation of a crystalline 1/1 molecular compound between trimethoprim and methyl parahydroxybenzoate is demonstrated by differential scanning calorimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy, and solid-state C-13-NMR. Interactions between trimethoprim and 4-hydroxybenzoic acid and its ethyl,propyl and butyl esters were not observed. The nature of the trimethoprim and methyl parahydroxybenzoate intermolecular bonding is discussed briefly.
AB - Solid-state interactions between trimethoprim and the esters of 4-hydroxybenzoic acid (parahydroxybenzoates or parabens) used for anti-microbial preservation are investigated. The formation of a crystalline 1/1 molecular compound between trimethoprim and methyl parahydroxybenzoate is demonstrated by differential scanning calorimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy, and solid-state C-13-NMR. Interactions between trimethoprim and 4-hydroxybenzoic acid and its ethyl,propyl and butyl esters were not observed. The nature of the trimethoprim and methyl parahydroxybenzoate intermolecular bonding is discussed briefly.
KW - interactions trimethoprim parabens differential scanning calorimetry c-13-nmr fourier transform infrared spectroscopy 1-1 molecular-compound
M3 - Tidsskriftartikel
VL - 4
SP - 292
EP - 297
JO - STP pharma sciences
JF - STP pharma sciences
SN - 1157-1489
IS - 4
ER -
ID: 38062149