Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems. / Svagan, Anna J; Benjamins, Jan-Willem; Al-Ansari, Zeinab; Shalom, Daniel Bar; Müllertz, Anette; Wågberg, Lars; Löbmann, Korbinian.

In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 244 , No. Part A, 12.11.2016, p. 74–82.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Svagan, AJ, Benjamins, J-W, Al-Ansari, Z, Shalom, DB, Müllertz, A, Wågberg, L & Löbmann, K 2016, 'Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems', Journal of controlled release : official journal of the Controlled Release Society, vol. 244 , no. Part A, pp. 74–82. https://doi.org/10.1016/j.jconrel.2016.11.009

APA

Svagan, A. J., Benjamins, J-W., Al-Ansari, Z., Shalom, D. B., Müllertz, A., Wågberg, L., & Löbmann, K. (2016). Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems. Journal of controlled release : official journal of the Controlled Release Society, 244 (Part A), 74–82. https://doi.org/10.1016/j.jconrel.2016.11.009

Vancouver

Svagan AJ, Benjamins J-W, Al-Ansari Z, Shalom DB, Müllertz A, Wågberg L et al. Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems. Journal of controlled release : official journal of the Controlled Release Society. 2016 Nov 12;244 (Part A):74–82. https://doi.org/10.1016/j.jconrel.2016.11.009

Author

Svagan, Anna J ; Benjamins, Jan-Willem ; Al-Ansari, Zeinab ; Shalom, Daniel Bar ; Müllertz, Anette ; Wågberg, Lars ; Löbmann, Korbinian. / Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems. In: Journal of controlled release : official journal of the Controlled Release Society. 2016 ; Vol. 244 , No. Part A. pp. 74–82.

Bibtex

@article{1bf76f91662b4b16a897ce2f16742d62,
title = "Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems",
abstract = "Control of drug action through formulation is a vital and very challenging topic within pharmaceutical sciences. Cellulose nanofibers (CNF) are an excipient candidate in pharmaceutical formulations that could be used to easily optimize drug delivery rates. CNF has interesting physico-chemical properties that, when combined with surfactants, can be used to create very stable air bubbles and dry foams. Utilizing this inherent property, it is possible to modify the release kinetics of the model drug riboflavin in a facile way. Wet foams were prepared using cationic CNF and a pharmaceutically acceptable surfactant (lauric acid sodium salt). The drug was suspended in the wet-stable foams followed by a drying step to obtain dry foams. Flexible cellular solid materials of different thicknesses, shapes and drug loadings (up to 50wt{\%}) could successfully be prepared. The drug was released from the solid foams in a diffusion-controlled, sustained manner due to the presence of intact air bubbles which imparted a tortuous diffusion path. The diffusion coefficient was assessed using Franz cells and shown to be more than one order of magnitude lower for the cellular solids compared to the bubble-free films in the wet state. By changing the dimensions of dry foams while keeping drug load and total weight constant, the drug release kinetics could be modified, e.g. a rectangular box-shaped foam of 8mm thickness released only 59{\%} of the drug after 24h whereas a thinner foam sample (0.6mm) released 78{\%} of its drug content within 8h. In comparison, the drug release from films (0.009mm, with the same total mass and an outer surface area comparable to the thinner foam) was much faster, amounting to 72{\%} of the drug within 1h. The entrapped air bubbles in the foam also induced positive buoyancy, which is interesting from the perspective of gastro-retentive drug-delivery.",
author = "Svagan, {Anna J} and Jan-Willem Benjamins and Zeinab Al-Ansari and Shalom, {Daniel Bar} and Anette M{\"u}llertz and Lars W{\aa}gberg and Korbinian L{\"o}bmann",
note = "Copyright {\circledC} 2016. Published by Elsevier B.V.",
year = "2016",
month = "11",
day = "12",
doi = "10.1016/j.jconrel.2016.11.009",
language = "English",
volume = "244",
pages = "74–82",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier",
number = "Part A",

}

RIS

TY - JOUR

T1 - Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems

AU - Svagan, Anna J

AU - Benjamins, Jan-Willem

AU - Al-Ansari, Zeinab

AU - Shalom, Daniel Bar

AU - Müllertz, Anette

AU - Wågberg, Lars

AU - Löbmann, Korbinian

N1 - Copyright © 2016. Published by Elsevier B.V.

PY - 2016/11/12

Y1 - 2016/11/12

N2 - Control of drug action through formulation is a vital and very challenging topic within pharmaceutical sciences. Cellulose nanofibers (CNF) are an excipient candidate in pharmaceutical formulations that could be used to easily optimize drug delivery rates. CNF has interesting physico-chemical properties that, when combined with surfactants, can be used to create very stable air bubbles and dry foams. Utilizing this inherent property, it is possible to modify the release kinetics of the model drug riboflavin in a facile way. Wet foams were prepared using cationic CNF and a pharmaceutically acceptable surfactant (lauric acid sodium salt). The drug was suspended in the wet-stable foams followed by a drying step to obtain dry foams. Flexible cellular solid materials of different thicknesses, shapes and drug loadings (up to 50wt%) could successfully be prepared. The drug was released from the solid foams in a diffusion-controlled, sustained manner due to the presence of intact air bubbles which imparted a tortuous diffusion path. The diffusion coefficient was assessed using Franz cells and shown to be more than one order of magnitude lower for the cellular solids compared to the bubble-free films in the wet state. By changing the dimensions of dry foams while keeping drug load and total weight constant, the drug release kinetics could be modified, e.g. a rectangular box-shaped foam of 8mm thickness released only 59% of the drug after 24h whereas a thinner foam sample (0.6mm) released 78% of its drug content within 8h. In comparison, the drug release from films (0.009mm, with the same total mass and an outer surface area comparable to the thinner foam) was much faster, amounting to 72% of the drug within 1h. The entrapped air bubbles in the foam also induced positive buoyancy, which is interesting from the perspective of gastro-retentive drug-delivery.

AB - Control of drug action through formulation is a vital and very challenging topic within pharmaceutical sciences. Cellulose nanofibers (CNF) are an excipient candidate in pharmaceutical formulations that could be used to easily optimize drug delivery rates. CNF has interesting physico-chemical properties that, when combined with surfactants, can be used to create very stable air bubbles and dry foams. Utilizing this inherent property, it is possible to modify the release kinetics of the model drug riboflavin in a facile way. Wet foams were prepared using cationic CNF and a pharmaceutically acceptable surfactant (lauric acid sodium salt). The drug was suspended in the wet-stable foams followed by a drying step to obtain dry foams. Flexible cellular solid materials of different thicknesses, shapes and drug loadings (up to 50wt%) could successfully be prepared. The drug was released from the solid foams in a diffusion-controlled, sustained manner due to the presence of intact air bubbles which imparted a tortuous diffusion path. The diffusion coefficient was assessed using Franz cells and shown to be more than one order of magnitude lower for the cellular solids compared to the bubble-free films in the wet state. By changing the dimensions of dry foams while keeping drug load and total weight constant, the drug release kinetics could be modified, e.g. a rectangular box-shaped foam of 8mm thickness released only 59% of the drug after 24h whereas a thinner foam sample (0.6mm) released 78% of its drug content within 8h. In comparison, the drug release from films (0.009mm, with the same total mass and an outer surface area comparable to the thinner foam) was much faster, amounting to 72% of the drug within 1h. The entrapped air bubbles in the foam also induced positive buoyancy, which is interesting from the perspective of gastro-retentive drug-delivery.

U2 - 10.1016/j.jconrel.2016.11.009

DO - 10.1016/j.jconrel.2016.11.009

M3 - Journal article

C2 - 27847327

VL - 244

SP - 74

EP - 82

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

IS - Part A

ER -

ID: 169101146