TY - JOUR

T1 - Skin absorption through atopic dermatitis skin

T2 - a systematic review

AU - Halling-Overgaard, A-S

AU - Kezic, S

AU - Jakasa, I

AU - Engebretsen, K A

AU - Maibach, H

AU - Thyssen, J P

N1 - This article is protected by copyright. All rights reserved.

PY - 2017/7

Y1 - 2017/7

N2 - Patients with atopic dermatitis have skin barrier impairment in both lesional and non-lesional skin. They are typically exposed to emollients daily and topical anti-inflammatory medicaments intermittently, hereby increasing the risk of developing contact allergy and systemic exposed to chemicals ingredients found in these topical preparations. We systematically searched for studies that investigated skin absorption of various penetrants, including medicaments, in atopic dermatitis patients, but also animals with experimentally induced dermatitis. We identified 40 articles, i.e. 11 human studies examining model penetrants, 26 human studies examining atopic dermatitis drugs and 3 animal studies. We conclude that atopic dermatitis patients have nearly two-fold increased skin absorption when compared to healthy controls. There is a need for well-designed epidemiological and dermato-pharmacokinetic studies that examine to what extent atopic dermatitis patients are systemically exposed to chemicals compared to non-atopics. This article is protected by copyright. All rights reserved.

AB - Patients with atopic dermatitis have skin barrier impairment in both lesional and non-lesional skin. They are typically exposed to emollients daily and topical anti-inflammatory medicaments intermittently, hereby increasing the risk of developing contact allergy and systemic exposed to chemicals ingredients found in these topical preparations. We systematically searched for studies that investigated skin absorption of various penetrants, including medicaments, in atopic dermatitis patients, but also animals with experimentally induced dermatitis. We identified 40 articles, i.e. 11 human studies examining model penetrants, 26 human studies examining atopic dermatitis drugs and 3 animal studies. We conclude that atopic dermatitis patients have nearly two-fold increased skin absorption when compared to healthy controls. There is a need for well-designed epidemiological and dermato-pharmacokinetic studies that examine to what extent atopic dermatitis patients are systemically exposed to chemicals compared to non-atopics. This article is protected by copyright. All rights reserved.

U2 - 10.1111/bjd.15065

DO - 10.1111/bjd.15065

M3 - Review

C2 - 27639188

VL - 177

SP - 84

EP - 106

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 1

ER -