Serum concentrations of buprenorphine after oral and parenteral administration in male mice

Research output: Contribution to journal › Journal article › Research › peer-review

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Serum concentrations of buprenorphine after oral and parenteral administration in male mice. / Kalliokoski, Otto; Jacobsen, Kirsten R; Hau, Jann; Abelson, Klas.

In: Veterinary Journal, Vol. 187, No. 2, 2011, p. 251-254.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kalliokoski, O, Jacobsen, KR, Hau, J & Abelson, K 2011, 'Serum concentrations of buprenorphine after oral and parenteral administration in male mice', Veterinary Journal, vol. 187, no. 2, pp. 251-254. https://doi.org/10.1016/j.tvjl.2009.11.013

APA

Kalliokoski, O., Jacobsen, K. R., Hau, J., & Abelson, K. (2011). Serum concentrations of buprenorphine after oral and parenteral administration in male mice. Veterinary Journal, 187(2), 251-254. https://doi.org/10.1016/j.tvjl.2009.11.013

Vancouver

Kalliokoski O, Jacobsen KR, Hau J, Abelson K. Serum concentrations of buprenorphine after oral and parenteral administration in male mice. Veterinary Journal. 2011;187(2):251-254. https://doi.org/10.1016/j.tvjl.2009.11.013

Author

Kalliokoski, Otto ; Jacobsen, Kirsten R ; Hau, Jann ; Abelson, Klas. / Serum concentrations of buprenorphine after oral and parenteral administration in male mice. In: Veterinary Journal. 2011 ; Vol. 187, No. 2. pp. 251-254.

Bibtex

@article{b77086103bf711df928f000ea68e967b,

title = "Serum concentrations of buprenorphine after oral and parenteral administration in male mice",

abstract = "Buprenorphine is the most commonly used drug for peri-operative pain relief in laboratory rodents. The systemic concentrations of buprenorphine were measured in mice following administration intravenously (IV), subcutaneously (SC), orally by gavage and by voluntary ingestion, to determine the post-administration serum concentration of buprenorphine. Voluntarily ingested buprenorphine resulted in long-lasting high serum concentrations, as did oral gavage administration (24h serum concentration: 110ngh/mL for both routes of administration). In contrast, buprenorphine administered parenterally remained in the circulation for a substantially shorter time (24h serum concentration for IV and SC were 40ngh/mL and 30ngh/mL, respectively). This marked difference was probably due to the higher dose used for oral administration, which is regarded necessary for sufficient analgesic effect, and to the slower absorption of the oral boli, as well as saturation of the hepatic buprenorphine metabolising pathways. Voluntary ingestion of buprenorphine was found to constitute a practical way to provide laboratory mice with efficient pain relief.",

author = "Otto Kalliokoski and Jacobsen, {Kirsten R} and Jann Hau and Klas Abelson",

year = "2011",

doi = "10.1016/j.tvjl.2009.11.013",

language = "English",

volume = "187",

pages = "251--254",

journal = "The Veterinary Journal",

issn = "1090-0233",

publisher = "Elsevier",

number = "2",

}

RIS

TY - JOUR

T1 - Serum concentrations of buprenorphine after oral and parenteral administration in male mice

AU - Kalliokoski, Otto

AU - Jacobsen, Kirsten R

AU - Hau, Jann

AU - Abelson, Klas

PY - 2011

Y1 - 2011

N2 - Buprenorphine is the most commonly used drug for peri-operative pain relief in laboratory rodents. The systemic concentrations of buprenorphine were measured in mice following administration intravenously (IV), subcutaneously (SC), orally by gavage and by voluntary ingestion, to determine the post-administration serum concentration of buprenorphine. Voluntarily ingested buprenorphine resulted in long-lasting high serum concentrations, as did oral gavage administration (24h serum concentration: 110ngh/mL for both routes of administration). In contrast, buprenorphine administered parenterally remained in the circulation for a substantially shorter time (24h serum concentration for IV and SC were 40ngh/mL and 30ngh/mL, respectively). This marked difference was probably due to the higher dose used for oral administration, which is regarded necessary for sufficient analgesic effect, and to the slower absorption of the oral boli, as well as saturation of the hepatic buprenorphine metabolising pathways. Voluntary ingestion of buprenorphine was found to constitute a practical way to provide laboratory mice with efficient pain relief.

AB - Buprenorphine is the most commonly used drug for peri-operative pain relief in laboratory rodents. The systemic concentrations of buprenorphine were measured in mice following administration intravenously (IV), subcutaneously (SC), orally by gavage and by voluntary ingestion, to determine the post-administration serum concentration of buprenorphine. Voluntarily ingested buprenorphine resulted in long-lasting high serum concentrations, as did oral gavage administration (24h serum concentration: 110ngh/mL for both routes of administration). In contrast, buprenorphine administered parenterally remained in the circulation for a substantially shorter time (24h serum concentration for IV and SC were 40ngh/mL and 30ngh/mL, respectively). This marked difference was probably due to the higher dose used for oral administration, which is regarded necessary for sufficient analgesic effect, and to the slower absorption of the oral boli, as well as saturation of the hepatic buprenorphine metabolising pathways. Voluntary ingestion of buprenorphine was found to constitute a practical way to provide laboratory mice with efficient pain relief.

U2 - 10.1016/j.tvjl.2009.11.013

DO - 10.1016/j.tvjl.2009.11.013

M3 - Journal article

C2 - 20045358

VL - 187

SP - 251

EP - 254

JO - The Veterinary Journal

JF - The Veterinary Journal

SN - 1090-0233

IS - 2

ER -

ID: 18924094