Regulatory circuits controlling white versus brown adipocyte differentiation

Research output: Contribution to journalJournal articleResearchpeer-review

Adipose tissue is a major endocrine organ that exerts a profound influence on whole-body homoeostasis. Two types of adipose tissue exist in mammals: WAT (white adipose tissue) and BAT (brown adipose tissue). WAT stores energy and is the largest energy reserve in mammals, whereas BAT, expressing UCP1 (uncoupling protein 1), can dissipate energy through adaptive thermogenesis. In rodents, ample evidence supports BAT as an organ counteracting obesity, whereas less is known about the presence and significance of BAT in humans. Despite the different functions of white and brown adipocytes, knowledge of factors differentially influencing the formation of white and brown fat cells is sparse. Here we summarize recent progress in the molecular understanding of white versus brown adipocyte differentiation, including novel insights into transcriptional and signal transduction pathways. Since expression of UCP1 is the hallmark of BAT and a key factor determining energy expenditure, we also review conditions associated with enhanced energy expenditure and UCP1 expression in WAT that may provide information on processes involved in brown adipocyte differentiation.
Original languageEnglish
JournalBiochemical Journal
Issue number2
Pages (from-to)153–168
Publication statusPublished - 2006
Externally publishedYes

Bibliographical note

Key words: brown adipose tissue (BAT), peroxisome proliferator-activated receptor g co-activator 1a (PGC-1a), signalling, transcription, white adipose tissue (WAT).

ID: 14667393