Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels
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Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels. / Alstrøm, Jette Skov; Stroemlund, Line Waring; Nielsen, Morten Schak; MacAulay, Nanna.
In: Biochemical Society Transactions, Vol. 43, No. 3, 06.2015, p. 519-23.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels
AU - Alstrøm, Jette Skov
AU - Stroemlund, Line Waring
AU - Nielsen, Morten Schak
AU - MacAulay, Nanna
PY - 2015/6
Y1 - 2015/6
N2 - Connexin43 (Cx43) generates intercellular gap junction channels involved in, among others, cardiac and brain function. Gap junctions are formed by the docking of two hemichannels from neighbouring cells. Undocked Cx43 hemichannels can upon different stimuli open towards the extracellular matrix and allow transport of molecules such as fluorescent dyes and ATP. A range of phosphorylated amino acids have been detected in the C-terminus of Cx43 and their physiological role has been intensively studied both in the gap junctional form of Cx43 and in its hemichannel configuration. We present the current knowledge of protein kinase C (PKC)-dependent regulation of Cx43 and discuss the divergent results.
AB - Connexin43 (Cx43) generates intercellular gap junction channels involved in, among others, cardiac and brain function. Gap junctions are formed by the docking of two hemichannels from neighbouring cells. Undocked Cx43 hemichannels can upon different stimuli open towards the extracellular matrix and allow transport of molecules such as fluorescent dyes and ATP. A range of phosphorylated amino acids have been detected in the C-terminus of Cx43 and their physiological role has been intensively studied both in the gap junctional form of Cx43 and in its hemichannel configuration. We present the current knowledge of protein kinase C (PKC)-dependent regulation of Cx43 and discuss the divergent results.
U2 - 10.1042/BST20150040
DO - 10.1042/BST20150040
M3 - Journal article
C2 - 26009201
VL - 43
SP - 519
EP - 523
JO - Biochemical Society Transactions
JF - Biochemical Society Transactions
SN - 0300-5127
IS - 3
ER -
ID: 143665697