Patient-reported outcomes, health-related quality of life, and clinical outcomes for urothelial cancer patients receiving chemo-or immunotherapy: A real-life experience

Research output: Contribution to journalJournal articleResearchpeer-review


  • Fulltext

    Final published version, 1.97 MB, PDF document

Patients with urothelial cell carcinoma (UCC) often have comorbidities, which cause trouble for the completion of oncological treatment, and little is known about their quality of life (QoL). The aim of the present study was to obtain and describe patient-reported outcomes (PRO) and QoL data from UCC patients in the treatment for locally advanced muscle-invasive or metastatic UCC. A total of 79 patients with UCC completed four questionnaires (EORTC QLQ-C30, QLQ-BLM30, HADS, and select PRO-CTCAE™ questions) once weekly during their treatment. From those, 26 patients (33%) underwent neoadjuvant treatment for local disease while 53 patients (67%) were treated for metastatic disease. Of all patients, 54% did not complete the planned treatment due to progression, nephrotoxicity, death, or intolerable symptoms during treatment. The five most prevalent PRO-CTCAE grade ≥ 2 symptoms were frequent urination (37%), fatigue (35%), pain (31%), dry mouth (23%), and swelling of the arms or legs (23%). The baseline mean overall QoL was 61 (±SD 24) for all patients (neoadjuvant (73, ±SD 19) and metastatic (54, ±SD 24)) and remained stable over the course of treatment for both groups. A stable overall QoL was observed for the patients in this study. More than half of the patients did not, however, complete the planned treatment. Further supportive care is warranted for bladder cancer patients.

Original languageEnglish
Article number1852
JournalJournal of Clinical Medicine
Issue number9
Publication statusPublished - 2021

Bibliographical note

Funding Information:
One of the authors (SK) is thankful to SERB-DST, Govt of India for the award of Young Scientist under Start-up Research Grant. The authors are also thankful to Dr. S M Venkatapathi, Chairman, East Point Group of Institutions for providing infrastructural facilities and to Dr. B M Satish, Principal, East Point College of Engineering and Technology for his support and encouragement.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

    Research areas

  • Bladder cancer, Chemotherapy, Immunotherapy, Patient-reported outcomes, Quality of life, Side effects, Urothelial cell carcinoma

ID: 301457864