Partial agonists and subunit selectivity at NMDA receptors

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Subunit-selective ligands for glutamate receptors remains an area of interest as glutamate is the major excitatory neurotransmitter in the brain and involved in a number of diseased states in the central nervous system (CNS). Few subtype-selective ligands are known, especially among the N-methyl-D-aspartic acid (NMDA) receptor class. Development of these ligands seems to be a difficult task because of the conserved region in the binding site of the NMDA receptor subunits. A few scaffolds have been developed showing potential to differentiate between the NMDA receptors.
Original languageEnglish
JournalChemistry: A European Journal
Issue number47
Pages (from-to)13910-13918
Publication statusPublished - 17 Dec 2010

ID: 33701222