Osteopontin deficiency dampens the pro-atherogenic effect of uraemia

Research output: Contribution to journalJournal articleResearchpeer-review

  • Tanja Xenia Pedersen
  • Marie Madsen
  • Nanna Maria Junker Nielsen
  • Christoffersen, Christina
  • Jonas Vikeså
  • Susanne Bro
  • Anna Hultgårdh-Nilsson
  • Lars Bo Nielsen
Uraemia is a strong risk factor for cardiovascular disease. Osteopontin (OPN) is highly expressed in aortas of uraemic apolipoprotein E knockout (E KO) mice. OPN affects key atherogenic processes, i.e. inflammation and phenotypic modulation of smooth muscle cells (SMCs). We explored the role of OPN on vascular pathology in uraemic mice.
Original languageEnglish
JournalCardiovascular Research
Issue number3
Pages (from-to)352-9
Number of pages8
Publication statusPublished - 1 Jun 2013

ID: 45810489