Nuclear DNA damage signalling to mitochondria in ageing
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Nuclear DNA damage signalling to mitochondria in ageing. / Fang, Evandro Fei; Scheibye-Knudsen, Morten; Chua, Katrin F; Mattson, Mark P; Croteau, Deborah L; Bohr, Vilhelm A.
In: Nature Reviews. Molecular Cell Biology, Vol. 17, No. 5, 05.2016, p. 308-321.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Nuclear DNA damage signalling to mitochondria in ageing
AU - Fang, Evandro Fei
AU - Scheibye-Knudsen, Morten
AU - Chua, Katrin F
AU - Mattson, Mark P
AU - Croteau, Deborah L
AU - Bohr, Vilhelm A
PY - 2016/5
Y1 - 2016/5
N2 - Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead to increased healthspan. Emerging evidence suggests a crucial role for signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. An important initiator of NM signalling is nuclear DNA damage, which accumulates with age and may contribute to the development of age-associated diseases. DNA damage-dependent NM signalling constitutes a network that includes nuclear sirtuins and controls genomic stability and mitochondrial integrity. Pharmacological modulation of NM signalling is a promising novel approach for the prevention and treatment of age-associated diseases.
AB - Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead to increased healthspan. Emerging evidence suggests a crucial role for signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. An important initiator of NM signalling is nuclear DNA damage, which accumulates with age and may contribute to the development of age-associated diseases. DNA damage-dependent NM signalling constitutes a network that includes nuclear sirtuins and controls genomic stability and mitochondrial integrity. Pharmacological modulation of NM signalling is a promising novel approach for the prevention and treatment of age-associated diseases.
U2 - 10.1038/nrm.2016.14
DO - 10.1038/nrm.2016.14
M3 - Journal article
C2 - 26956196
VL - 17
SP - 308
EP - 321
JO - Nature Reviews. Molecular Cell Biology
JF - Nature Reviews. Molecular Cell Biology
SN - 1471-0072
IS - 5
ER -
ID: 172127641