Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. / Shehata, Mohamed A; Jensen, Anne Cathrine Nøhr; Lissa, Delphine; Bisig, Christoph; Isberg, Vignir; Andersen, Kirsten B; Harpsøe, Kasper; Björkling, Fredrik; Bräuner-Osborne, Hans; Gloriam, David E.

In: Scientific Reports, Vol. 6, 36681, 10.11.2016, p. 1-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Shehata, MA, Jensen, ACN, Lissa, D, Bisig, C, Isberg, V, Andersen, KB, Harpsøe, K, Björkling, F, Bräuner-Osborne, H & Gloriam, DE 2016, 'Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139', Scientific Reports, vol. 6, 36681, pp. 1-13. https://doi.org/10.1038/srep36681

APA

Shehata, M. A., Jensen, A. C. N., Lissa, D., Bisig, C., Isberg, V., Andersen, K. B., Harpsøe, K., Björkling, F., Bräuner-Osborne, H., & Gloriam, D. E. (2016). Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. Scientific Reports, 6, 1-13. [36681]. https://doi.org/10.1038/srep36681

Vancouver

Shehata MA, Jensen ACN, Lissa D, Bisig C, Isberg V, Andersen KB et al. Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. Scientific Reports. 2016 Nov 10;6:1-13. 36681. https://doi.org/10.1038/srep36681

Author

Shehata, Mohamed A ; Jensen, Anne Cathrine Nøhr ; Lissa, Delphine ; Bisig, Christoph ; Isberg, Vignir ; Andersen, Kirsten B ; Harpsøe, Kasper ; Björkling, Fredrik ; Bräuner-Osborne, Hans ; Gloriam, David E. / Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. In: Scientific Reports. 2016 ; Vol. 6. pp. 1-13.

Bibtex

@article{4d2df62f0a184246af349b87cc7b0b2d,
title = "Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139",
abstract = "GPR139 is an orphan class A G protein-coupled receptor found mainly in the central nervous system. It has its highest expression levels in the hypothalamus and striatum, regions regulating metabolism and locomotion, respectively, and has therefore been suggested as a potential target for obesity and Parkinson's disease. The two aromatic amino acids L-Trp and L-Phe have been proposed as putative endogenous agonists, and three structurally related benzohydrazide, glycine benzamide, and benzotriazine surrogate agonist series have been published. Herein, we assayed 158 new analogues selected from a pharmacophore model, and identified 12 new GPR139 agonists, containing previously untested bioisosteres. Furthermore, we present the first combined structure-activity relationships, and a refined pharmacophore model to serve as a rationale for future ligand identification and optimization.",
author = "Shehata, {Mohamed A} and Jensen, {Anne Cathrine N{\o}hr} and Delphine Lissa and Christoph Bisig and Vignir Isberg and Andersen, {Kirsten B} and Kasper Harps{\o}e and Fredrik Bj{\"o}rkling and Hans Br{\"a}uner-Osborne and Gloriam, {David E}",
year = "2016",
month = nov,
day = "10",
doi = "10.1038/srep36681",
language = "English",
volume = "6",
pages = "1--13",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139

AU - Shehata, Mohamed A

AU - Jensen, Anne Cathrine Nøhr

AU - Lissa, Delphine

AU - Bisig, Christoph

AU - Isberg, Vignir

AU - Andersen, Kirsten B

AU - Harpsøe, Kasper

AU - Björkling, Fredrik

AU - Bräuner-Osborne, Hans

AU - Gloriam, David E

PY - 2016/11/10

Y1 - 2016/11/10

N2 - GPR139 is an orphan class A G protein-coupled receptor found mainly in the central nervous system. It has its highest expression levels in the hypothalamus and striatum, regions regulating metabolism and locomotion, respectively, and has therefore been suggested as a potential target for obesity and Parkinson's disease. The two aromatic amino acids L-Trp and L-Phe have been proposed as putative endogenous agonists, and three structurally related benzohydrazide, glycine benzamide, and benzotriazine surrogate agonist series have been published. Herein, we assayed 158 new analogues selected from a pharmacophore model, and identified 12 new GPR139 agonists, containing previously untested bioisosteres. Furthermore, we present the first combined structure-activity relationships, and a refined pharmacophore model to serve as a rationale for future ligand identification and optimization.

AB - GPR139 is an orphan class A G protein-coupled receptor found mainly in the central nervous system. It has its highest expression levels in the hypothalamus and striatum, regions regulating metabolism and locomotion, respectively, and has therefore been suggested as a potential target for obesity and Parkinson's disease. The two aromatic amino acids L-Trp and L-Phe have been proposed as putative endogenous agonists, and three structurally related benzohydrazide, glycine benzamide, and benzotriazine surrogate agonist series have been published. Herein, we assayed 158 new analogues selected from a pharmacophore model, and identified 12 new GPR139 agonists, containing previously untested bioisosteres. Furthermore, we present the first combined structure-activity relationships, and a refined pharmacophore model to serve as a rationale for future ligand identification and optimization.

U2 - 10.1038/srep36681

DO - 10.1038/srep36681

M3 - Journal article

C2 - 27830715

VL - 6

SP - 1

EP - 13

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 36681

ER -

ID: 168780540