Natriuretic pro-peptides in idiopathic intracranial hypertension

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Idiopathic intracranial hypertension is a disorder of unknown pathogenesis. Natriuretic peptides may be involved in intracranial pressure regulation, but cerebrospinal fluid (CNS) and plasma concentrations in this disorder are unknown. We evaluated venous and intrathecal concentrations of ANP, BNP and CNP precursor peptides in 40 patients with idiopathic intracranial hypertension and in 20 controls. Natriuretic pro-peptides were quantitated using processing-independent assays. In CSF, no differences in peptide concentrations between patients and controls were found (proANP: 239 + or - 23 vs 231 + or - 22 pmol/L, proBNP:
Original languageEnglish
JournalRegulatory Peptides
Issue number2-3
Pages (from-to)71-7
Number of pages7
Publication statusPublished - 24 Sep 2010

ID: 34095481