Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: The Microalbuminuria Education and Medication Optimisation (MEMO) study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria : The Microalbuminuria Education and Medication Optimisation (MEMO) study. / Crasto, W.; Jarvis, J.; Khunti, K.; Skinner, T. C.; Gray, L. J.; Brela, J.; Troughton, J.; Daly, H.; Lawrence, I. G.; McNally, P. G.; Carey, M. E.; Davies, M. J.

In: Diabetes Research and Clinical Practice, Vol. 93, No. 3, 01.09.2011, p. 328-336.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Crasto, W, Jarvis, J, Khunti, K, Skinner, TC, Gray, LJ, Brela, J, Troughton, J, Daly, H, Lawrence, IG, McNally, PG, Carey, ME & Davies, MJ 2011, 'Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: The Microalbuminuria Education and Medication Optimisation (MEMO) study', Diabetes Research and Clinical Practice, vol. 93, no. 3, pp. 328-336. https://doi.org/10.1016/j.diabres.2011.05.008

APA

Crasto, W., Jarvis, J., Khunti, K., Skinner, T. C., Gray, L. J., Brela, J., Troughton, J., Daly, H., Lawrence, I. G., McNally, P. G., Carey, M. E., & Davies, M. J. (2011). Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: The Microalbuminuria Education and Medication Optimisation (MEMO) study. Diabetes Research and Clinical Practice, 93(3), 328-336. https://doi.org/10.1016/j.diabres.2011.05.008

Vancouver

Crasto W, Jarvis J, Khunti K, Skinner TC, Gray LJ, Brela J et al. Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: The Microalbuminuria Education and Medication Optimisation (MEMO) study. Diabetes Research and Clinical Practice. 2011 Sep 1;93(3):328-336. https://doi.org/10.1016/j.diabres.2011.05.008

Author

Crasto, W. ; Jarvis, J. ; Khunti, K. ; Skinner, T. C. ; Gray, L. J. ; Brela, J. ; Troughton, J. ; Daly, H. ; Lawrence, I. G. ; McNally, P. G. ; Carey, M. E. ; Davies, M. J. / Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria : The Microalbuminuria Education and Medication Optimisation (MEMO) study. In: Diabetes Research and Clinical Practice. 2011 ; Vol. 93, No. 3. pp. 328-336.

Bibtex

@article{08e3a31f9bc249e593b2dd4e6a1a1c90,
title = "Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: The Microalbuminuria Education and Medication Optimisation (MEMO) study",
abstract = "Aims: To determine whether tighter cardiovascular risk factor control with structured education in individuals with type 2 diabetes (T2DM) and microalbuminuria benefits cardiovascular risk factors. Methods: Participants from a multiethnic population, recruited from primary care and specialist clinics were randomised to intensive intervention with structured patient (DESMOND model) education (n= 94) or usual care by own health professional (n= 95). Primary outcome: change in HbA1c at 18. months. Secondary outcomes: changes in blood pressure (BP), cholesterol, albuminuria, proportion reaching risk factor targets, modelled cardiovascular risk scores. Results: Mean (SD) age and diabetes duration of participants were 61.5 (10.5) and 11.5 (9.3) years, respectively. At 18. months, intensive intervention showed significant improvements in HbA1c (7.1(1.0) vs. 7.8(1.4)%, p< 0.0001), systolic BP (129(16) vs. 139(17) mmHg, p< 0.0001), diastolic BP (70(11) vs. 76(12) mmHg, p< 0.001), total cholesterol (3.7(0.8) vs. 4.1(0.9) mmol/l, p= 0.001). Moderate and severe hypoglycaemia was 11.2 vs. 29.0%; p= 0.001 and 0 vs. 6.3%; p= 0.07, respectively. More intensive participants achieved ≥3 risk factor targets with greater reductions in cardiovascular risk scores. Conclusions: Intensive intervention showed greater improvements in metabolic control and cardiovascular risk profile with lower rates of moderate and severe hypoglycaemia. Intensive glycaemic interventions should be underpinned by structured education promoting self-management in T2DM.",
keywords = "Microalbuminuria, Structured education, Type 2 diabetes",
author = "W. Crasto and J. Jarvis and K. Khunti and Skinner, {T. C.} and Gray, {L. J.} and J. Brela and J. Troughton and H. Daly and Lawrence, {I. G.} and McNally, {P. G.} and Carey, {M. E.} and Davies, {M. J.}",
year = "2011",
month = sep,
day = "1",
doi = "10.1016/j.diabres.2011.05.008",
language = "English",
volume = "93",
pages = "328--336",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria

T2 - The Microalbuminuria Education and Medication Optimisation (MEMO) study

AU - Crasto, W.

AU - Jarvis, J.

AU - Khunti, K.

AU - Skinner, T. C.

AU - Gray, L. J.

AU - Brela, J.

AU - Troughton, J.

AU - Daly, H.

AU - Lawrence, I. G.

AU - McNally, P. G.

AU - Carey, M. E.

AU - Davies, M. J.

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Aims: To determine whether tighter cardiovascular risk factor control with structured education in individuals with type 2 diabetes (T2DM) and microalbuminuria benefits cardiovascular risk factors. Methods: Participants from a multiethnic population, recruited from primary care and specialist clinics were randomised to intensive intervention with structured patient (DESMOND model) education (n= 94) or usual care by own health professional (n= 95). Primary outcome: change in HbA1c at 18. months. Secondary outcomes: changes in blood pressure (BP), cholesterol, albuminuria, proportion reaching risk factor targets, modelled cardiovascular risk scores. Results: Mean (SD) age and diabetes duration of participants were 61.5 (10.5) and 11.5 (9.3) years, respectively. At 18. months, intensive intervention showed significant improvements in HbA1c (7.1(1.0) vs. 7.8(1.4)%, p< 0.0001), systolic BP (129(16) vs. 139(17) mmHg, p< 0.0001), diastolic BP (70(11) vs. 76(12) mmHg, p< 0.001), total cholesterol (3.7(0.8) vs. 4.1(0.9) mmol/l, p= 0.001). Moderate and severe hypoglycaemia was 11.2 vs. 29.0%; p= 0.001 and 0 vs. 6.3%; p= 0.07, respectively. More intensive participants achieved ≥3 risk factor targets with greater reductions in cardiovascular risk scores. Conclusions: Intensive intervention showed greater improvements in metabolic control and cardiovascular risk profile with lower rates of moderate and severe hypoglycaemia. Intensive glycaemic interventions should be underpinned by structured education promoting self-management in T2DM.

AB - Aims: To determine whether tighter cardiovascular risk factor control with structured education in individuals with type 2 diabetes (T2DM) and microalbuminuria benefits cardiovascular risk factors. Methods: Participants from a multiethnic population, recruited from primary care and specialist clinics were randomised to intensive intervention with structured patient (DESMOND model) education (n= 94) or usual care by own health professional (n= 95). Primary outcome: change in HbA1c at 18. months. Secondary outcomes: changes in blood pressure (BP), cholesterol, albuminuria, proportion reaching risk factor targets, modelled cardiovascular risk scores. Results: Mean (SD) age and diabetes duration of participants were 61.5 (10.5) and 11.5 (9.3) years, respectively. At 18. months, intensive intervention showed significant improvements in HbA1c (7.1(1.0) vs. 7.8(1.4)%, p< 0.0001), systolic BP (129(16) vs. 139(17) mmHg, p< 0.0001), diastolic BP (70(11) vs. 76(12) mmHg, p< 0.001), total cholesterol (3.7(0.8) vs. 4.1(0.9) mmol/l, p= 0.001). Moderate and severe hypoglycaemia was 11.2 vs. 29.0%; p= 0.001 and 0 vs. 6.3%; p= 0.07, respectively. More intensive participants achieved ≥3 risk factor targets with greater reductions in cardiovascular risk scores. Conclusions: Intensive intervention showed greater improvements in metabolic control and cardiovascular risk profile with lower rates of moderate and severe hypoglycaemia. Intensive glycaemic interventions should be underpinned by structured education promoting self-management in T2DM.

KW - Microalbuminuria

KW - Structured education

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=80052732201&partnerID=8YFLogxK

U2 - 10.1016/j.diabres.2011.05.008

DO - 10.1016/j.diabres.2011.05.008

M3 - Journal article

C2 - 21640424

AN - SCOPUS:80052732201

VL - 93

SP - 328

EP - 336

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 3

ER -

ID: 189874198