Monitoring tablet surface roughness during the film coating process
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Monitoring tablet surface roughness during the film coating process. / Seitavuopio, Paulus; Heinämäki, Jyrki; Rantanen, Jukka; Yliruusi, Jouko.
In: AAPS PharmSciTech, Vol. 7, No. 2, 2006, p. E31.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Monitoring tablet surface roughness during the film coating process
AU - Seitavuopio, Paulus
AU - Heinämäki, Jyrki
AU - Rantanen, Jukka
AU - Yliruusi, Jouko
PY - 2006
Y1 - 2006
N2 - The purpose of this study was to evaluate the change of surface roughness and the development of the film during the film coating process using laser profilometer roughness measurements, SEM imaging, and energy dispersive X-ray (EDX) analysis. Surface roughness and texture changes developing during the process of film coating tablets were studied by noncontact laser profilometry and scanning electron microscopy (SEM). An EDX analysis was used to monitor the magnesium stearate and titanium dioxide of the tablets. The tablet cores were film coated with aqueous hydroxypropyl methylcellulose, and the film coating was performed using an instrumented pilot-scale side-vented drum coater. The SEM images of the film-coated tablets showed that within the first 30 minutes, the surface of the tablet cores was completely covered with a thin film. The magnesium signal that was monitored by SEM-EDX disappeared after ~15 to 30 minutes, indicating that the tablet surface was homogeneously covered with film coating. The surface roughness started to increase from the beginning of the coating process, and the increase in the roughness broke off after 30 minutes of spraying. The results clearly showed that the surface roughness of the tablets increased until the film coating covered the whole surface area of the tablets, corresponding to a coating time period of 15 to 30 minutes (from the beginning of the spraying phase). Thereafter, the film only became thicker. The methods used in this study were applicable in the visualization of the changes caused by the film coating on the tablet surfaces.
AB - The purpose of this study was to evaluate the change of surface roughness and the development of the film during the film coating process using laser profilometer roughness measurements, SEM imaging, and energy dispersive X-ray (EDX) analysis. Surface roughness and texture changes developing during the process of film coating tablets were studied by noncontact laser profilometry and scanning electron microscopy (SEM). An EDX analysis was used to monitor the magnesium stearate and titanium dioxide of the tablets. The tablet cores were film coated with aqueous hydroxypropyl methylcellulose, and the film coating was performed using an instrumented pilot-scale side-vented drum coater. The SEM images of the film-coated tablets showed that within the first 30 minutes, the surface of the tablet cores was completely covered with a thin film. The magnesium signal that was monitored by SEM-EDX disappeared after ~15 to 30 minutes, indicating that the tablet surface was homogeneously covered with film coating. The surface roughness started to increase from the beginning of the coating process, and the increase in the roughness broke off after 30 minutes of spraying. The results clearly showed that the surface roughness of the tablets increased until the film coating covered the whole surface area of the tablets, corresponding to a coating time period of 15 to 30 minutes (from the beginning of the spraying phase). Thereafter, the film only became thicker. The methods used in this study were applicable in the visualization of the changes caused by the film coating on the tablet surfaces.
KW - Coated Materials, Biocompatible
KW - Drug Compounding
KW - Hypromellose Derivatives
KW - Materials Testing
KW - Membranes, Artificial
KW - Methylcellulose
KW - Stearic Acids
KW - Surface Properties
KW - Tablets
KW - Titanium
U2 - 10.1208/pt070231
DO - 10.1208/pt070231
M3 - Journal article
C2 - 16796349
VL - 7
SP - E31
JO - AAPS PharmSciTech
JF - AAPS PharmSciTech
SN - 1530-9932
IS - 2
ER -
ID: 140618757