Model of a sub-main transition in phospholipid bilayers
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A recently discovered submain phase transition in multi-lamellar bilayers of long-chain saturated diacyl phosphatidylcholines (Jorgensen, K. (1995) Biochim. Biophys. Acta 1240, 111-114) is discussed in terms of a theoretical molecular interaction model using computer simulation techniques. The model interprets the transition to be due to a decoupling of the acyl-chain melting from the melting of the pseudo-two-dimensional crystalline lattice of the P(β') phase. A two-stage melting process is predicted by the calculations suggesting that the sub-main transition involves a lattice melting whereas the acyl-chain melting takes place at a higher temperature at the main transition. The calculated heat contents of the two transitions as well as the chain-length dependence compare favorably with experimental data for multi-lamellar phosphatidylcholine lipid bilayers.
|Journal||Biochimica et Biophysica Acta - Biomembranes|
|Number of pages||7|
|Publication status||Published - 4 Sep 1996|
- Calorimetry, Chain melting, Lattice melting, Lipid bilayer, Phospholipid, Submain phase transition, Theoretical model