Miscibility and interactions between 17beta-estradiol and Eudragit RS in solid dispersion
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Miscibility and interactions between 17beta-estradiol and Eudragit RS in solid dispersion. / Wiranidchapong, Chutima; Tucker, Ian G; Rades, Thomas; Kulvanich, Poj.
In: Al Azhar Journal of Pharmaceutical Sciences, Vol. 97, No. 11, 2008, p. 4879-88.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Miscibility and interactions between 17beta-estradiol and Eudragit RS in solid dispersion
AU - Wiranidchapong, Chutima
AU - Tucker, Ian G
AU - Rades, Thomas
AU - Kulvanich, Poj
PY - 2008
Y1 - 2008
N2 - Miscibility of 17beta-estradiol and Eudragit RS in solid dispersions was determined by modulated temperature differential scanning calorimetry (MTDSC). A reduction of the 17beta-estradiol melting point in Eudragit RS solid dispersions was observed by MTDSC using heating program I in which the maximum temperature in the first heating run was lower than the 17beta-estradiol melting point. The melting point depression of 17beta-estradiol in solid dispersions as a function of composition could be explained by the Nishi-Wang equation indicating an interaction between 17beta-estradiol and Eudragit RS in the system. A variation of glass transition temperature (T(g)) of 17beta-estradiol in Eudragit RS solid dispersion was observed by MTDSC using heating program II in which the maximum temperature in the first heating run reached the 17beta-estradiol melting point. In the second heating run of heating program II, 17beta-estradiol was in an amorphous form blended with Eudragit RS. The variation in T(g) of amorphous 17beta-estradiol blended with Eudragit RS could be explained by the Kwei equation, a modified version of the Gordon-Taylor equation. The parameter estimates from the Kwei equation were consistent with an interaction between 17beta-estradiol and Eudragit RS, which was due to inter-associated hydrogen bonding as deduced from the FTIR spectra of the blends.
AB - Miscibility of 17beta-estradiol and Eudragit RS in solid dispersions was determined by modulated temperature differential scanning calorimetry (MTDSC). A reduction of the 17beta-estradiol melting point in Eudragit RS solid dispersions was observed by MTDSC using heating program I in which the maximum temperature in the first heating run was lower than the 17beta-estradiol melting point. The melting point depression of 17beta-estradiol in solid dispersions as a function of composition could be explained by the Nishi-Wang equation indicating an interaction between 17beta-estradiol and Eudragit RS in the system. A variation of glass transition temperature (T(g)) of 17beta-estradiol in Eudragit RS solid dispersion was observed by MTDSC using heating program II in which the maximum temperature in the first heating run reached the 17beta-estradiol melting point. In the second heating run of heating program II, 17beta-estradiol was in an amorphous form blended with Eudragit RS. The variation in T(g) of amorphous 17beta-estradiol blended with Eudragit RS could be explained by the Kwei equation, a modified version of the Gordon-Taylor equation. The parameter estimates from the Kwei equation were consistent with an interaction between 17beta-estradiol and Eudragit RS, which was due to inter-associated hydrogen bonding as deduced from the FTIR spectra of the blends.
U2 - 10.1002/jps.21366
DO - 10.1002/jps.21366
M3 - Journal article
C2 - 18351595
VL - 97
SP - 4879
EP - 4888
JO - Al Azhar Journal of Pharmaceutical Sciences
JF - Al Azhar Journal of Pharmaceutical Sciences
SN - 1110-1644
IS - 11
ER -
ID: 40353674