Kinetics of 5-aminosalicylic acid after jejunal instillation in man

Research output: Contribution to journalJournal articleResearchpeer-review

The human pharmacokinetics of 5-aminosalicylic acid (5-ASA), the active moiety of salazosulphapyridine (SASP), is only known from studies in which rapid absorption has been deliberately avoided. The present investigation demonstrates that pure 5-ASA is absorbed extremely quickly when given as an instillation in the proximal part of the small bowel, and acetylation follows immediately. The metabolite is excreted very rapidly by the liver in small amounts, while the major part is eliminated renally.

Original languageEnglish
JournalBritish Journal of Clinical Pharmacology. Supplement
Issue number6
Pages (from-to)738-40
Number of pages3
Publication statusPublished - Dec 1983
Externally publishedYes

    Research areas

  • Acetylation, Adult, Aminosalicylic Acids/administration & dosage, Female, Humans, Intestinal Absorption, Jejunum/metabolism, Kinetics, Male, Mesalamine

ID: 219533969