Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells: synergy with interleukin-1beta and tumor necrosis factor-alpha

Research output: Contribution to journalJournal articleResearchpeer-review

Interstitial cystitis is characterized by an increased number of activated MCs in the detrusor muscle. However, to our knowledge the factors that influence the anatomical relationship between MCs and HDSMCs are unknown. MCP-1, IL-6 and SCF have a critical role in the regulation of MC development, signaling and function. We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha.
Original languageEnglish
JournalJournal of Urology
Issue number2
Pages (from-to)760-5
Number of pages6
Publication statusPublished - 2006

    Research areas

  • Cells, Cultured, Chemokine CCL2, Humans, Interleukin-1, Interleukin-13, Interleukin-4, Interleukin-6, Muscle, Smooth, Stem Cell Factor, Tumor Necrosis Factor-alpha

ID: 35922410