Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells: synergy with interleukin-1beta and tumor necrosis factor-alpha
Research output: Contribution to journal › Journal article › Research › peer-review
Interstitial cystitis is characterized by an increased number of activated MCs in the detrusor muscle. However, to our knowledge the factors that influence the anatomical relationship between MCs and HDSMCs are unknown. MCP-1, IL-6 and SCF have a critical role in the regulation of MC development, signaling and function. We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha.
|Journal||Journal of Urology|
|Number of pages||6|
|Publication status||Published - 2006|
- Cells, Cultured, Chemokine CCL2, Humans, Interleukin-1, Interleukin-13, Interleukin-4, Interleukin-6, Muscle, Smooth, Stem Cell Factor, Tumor Necrosis Factor-alpha