Influence of Polymer Molecular Weight on Drug-Polymer Solubility: A Comparison between Experimentally Determined Solubility in PVP and Prediction Derived from Solubility in Monomer

Research output: Contribution to journalJournal articlepeer-review

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Influence of Polymer Molecular Weight on Drug-Polymer Solubility : A Comparison between Experimentally Determined Solubility in PVP and Prediction Derived from Solubility in Monomer. / Knopp, Matthias Manne; Olesen, Niels Erik; Holm, Per; Langguth, Peter; Holm, René; Rades, Thomas.

In: Journal of Pharmaceutical Sciences, Vol. 104, No. 9, 03.03.2015, p. 2905–2912.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Knopp, MM, Olesen, NE, Holm, P, Langguth, P, Holm, R & Rades, T 2015, 'Influence of Polymer Molecular Weight on Drug-Polymer Solubility: A Comparison between Experimentally Determined Solubility in PVP and Prediction Derived from Solubility in Monomer', Journal of Pharmaceutical Sciences, vol. 104, no. 9, pp. 2905–2912. https://doi.org/10.1002/jps.24410

APA

Knopp, M. M., Olesen, N. E., Holm, P., Langguth, P., Holm, R., & Rades, T. (2015). Influence of Polymer Molecular Weight on Drug-Polymer Solubility: A Comparison between Experimentally Determined Solubility in PVP and Prediction Derived from Solubility in Monomer. Journal of Pharmaceutical Sciences, 104(9), 2905–2912. https://doi.org/10.1002/jps.24410

Vancouver

Knopp MM, Olesen NE, Holm P, Langguth P, Holm R, Rades T. Influence of Polymer Molecular Weight on Drug-Polymer Solubility: A Comparison between Experimentally Determined Solubility in PVP and Prediction Derived from Solubility in Monomer. Journal of Pharmaceutical Sciences. 2015 Mar 3;104(9):2905–2912. https://doi.org/10.1002/jps.24410

Author

Knopp, Matthias Manne ; Olesen, Niels Erik ; Holm, Per ; Langguth, Peter ; Holm, René ; Rades, Thomas. / Influence of Polymer Molecular Weight on Drug-Polymer Solubility : A Comparison between Experimentally Determined Solubility in PVP and Prediction Derived from Solubility in Monomer. In: Journal of Pharmaceutical Sciences. 2015 ; Vol. 104, No. 9. pp. 2905–2912.

Bibtex

@article{36db200fc40043ddb469aa0a8ace3f7e,
title = "Influence of Polymer Molecular Weight on Drug-Polymer Solubility: A Comparison between Experimentally Determined Solubility in PVP and Prediction Derived from Solubility in Monomer",
abstract = "In this study, the influence of polymer molecular weight on drug-polymer solubility was investigated using binary systems containing indomethacin (IMC) and polyvinylpyrrolidone (PVP) of different molecular weights. The experimental solubility in PVP, measured using a differential scanning calorimetry annealing method, was compared with the solubility calculated from the solubility of the drug in the liquid analogue N-vinylpyrrolidone (NVP). The experimental solubility of IMC in the low-molecular-weight PVP K12 was not significantly different from that in the higher molecular weight PVPs (K25, K30, and K90). The calculated solubilities derived from the solubility in NVP (0.31-0.32 g/g) were found to be lower than those experimentally determined in PVP (0.38-0.40 g/g). Nevertheless, the similarity between the values indicates that the analogue solubility can provide valuable indications on the solubility in the polymer. Hence, if a drug is soluble in an analogue of the polymer, it is most likely also soluble in the polymer. In conclusion, the solubility of a given drug-polymer system is determined by the strength of the drug-polymer interactions rather than the molecular weight of the polymer. Therefore, during the first screenings for drug solubility in polymers, only one representative molecular weight per polymer is needed.",
author = "Knopp, {Matthias Manne} and Olesen, {Niels Erik} and Per Holm and Peter Langguth and Ren{\'e} Holm and Thomas Rades",
note = "{\textcopyright} 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.",
year = "2015",
month = mar,
day = "3",
doi = "10.1002/jps.24410",
language = "English",
volume = "104",
pages = "2905–2912",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - Influence of Polymer Molecular Weight on Drug-Polymer Solubility

T2 - A Comparison between Experimentally Determined Solubility in PVP and Prediction Derived from Solubility in Monomer

AU - Knopp, Matthias Manne

AU - Olesen, Niels Erik

AU - Holm, Per

AU - Langguth, Peter

AU - Holm, René

AU - Rades, Thomas

N1 - © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.

PY - 2015/3/3

Y1 - 2015/3/3

N2 - In this study, the influence of polymer molecular weight on drug-polymer solubility was investigated using binary systems containing indomethacin (IMC) and polyvinylpyrrolidone (PVP) of different molecular weights. The experimental solubility in PVP, measured using a differential scanning calorimetry annealing method, was compared with the solubility calculated from the solubility of the drug in the liquid analogue N-vinylpyrrolidone (NVP). The experimental solubility of IMC in the low-molecular-weight PVP K12 was not significantly different from that in the higher molecular weight PVPs (K25, K30, and K90). The calculated solubilities derived from the solubility in NVP (0.31-0.32 g/g) were found to be lower than those experimentally determined in PVP (0.38-0.40 g/g). Nevertheless, the similarity between the values indicates that the analogue solubility can provide valuable indications on the solubility in the polymer. Hence, if a drug is soluble in an analogue of the polymer, it is most likely also soluble in the polymer. In conclusion, the solubility of a given drug-polymer system is determined by the strength of the drug-polymer interactions rather than the molecular weight of the polymer. Therefore, during the first screenings for drug solubility in polymers, only one representative molecular weight per polymer is needed.

AB - In this study, the influence of polymer molecular weight on drug-polymer solubility was investigated using binary systems containing indomethacin (IMC) and polyvinylpyrrolidone (PVP) of different molecular weights. The experimental solubility in PVP, measured using a differential scanning calorimetry annealing method, was compared with the solubility calculated from the solubility of the drug in the liquid analogue N-vinylpyrrolidone (NVP). The experimental solubility of IMC in the low-molecular-weight PVP K12 was not significantly different from that in the higher molecular weight PVPs (K25, K30, and K90). The calculated solubilities derived from the solubility in NVP (0.31-0.32 g/g) were found to be lower than those experimentally determined in PVP (0.38-0.40 g/g). Nevertheless, the similarity between the values indicates that the analogue solubility can provide valuable indications on the solubility in the polymer. Hence, if a drug is soluble in an analogue of the polymer, it is most likely also soluble in the polymer. In conclusion, the solubility of a given drug-polymer system is determined by the strength of the drug-polymer interactions rather than the molecular weight of the polymer. Therefore, during the first screenings for drug solubility in polymers, only one representative molecular weight per polymer is needed.

U2 - 10.1002/jps.24410

DO - 10.1002/jps.24410

M3 - Journal article

C2 - 25740567

VL - 104

SP - 2905

EP - 2912

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 9

ER -

ID: 137373672