Human migraine models
Research output: Contribution to journal › Journal article › peer-review
The need for experimental models is obvious. In animal models it is possible to study vascular responses, neurogenic inflammation, c-fos expression etc. However, the pathophysiology of migraine remains unsolved, why results from animal studies not directly can be related to the migraine attack, which is a human experience. A set-up for investigations of experimental headache and migraine in humans, has been evaluated and headache mechanisms explored by using nitroglycerin and other headache-inducing agents. Nitric oxide (NO) or other parts of the NO activated cascade seems to be responsible for the induced headache and migraine. Perspectives are discussed.
|Journal||Cephalalgia : an international journal of headache|
|Number of pages||5|
|Publication status||Published - Sep 2001|
- Animals, Cerebrovascular Circulation, Humans, Migraine Disorders, Models, Neurological, Nitroglycerin, Vasodilator Agents