Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. / Jansen, S W; Akintola, A A; Roelfsema, F; van der Spoel, E; Cobbaert, C M; Ballieux, B E; Egri, P; Kvarta-Papp, Z; Gereben, B; Fekete, C; Slagboom, P E; van der Grond, J; Demeneix, B A; Pijl, H; Westendorp, Rudi GJ; van Heemst, D.

In: Scientific Reports, Vol. 5, 11525 , 2015.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jansen, SW, Akintola, AA, Roelfsema, F, van der Spoel, E, Cobbaert, CM, Ballieux, BE, Egri, P, Kvarta-Papp, Z, Gereben, B, Fekete, C, Slagboom, PE, van der Grond, J, Demeneix, BA, Pijl, H, Westendorp, RGJ & van Heemst, D 2015, 'Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism', Scientific Reports, vol. 5, 11525 . https://doi.org/10.1038/srep11525

APA

Jansen, S. W., Akintola, A. A., Roelfsema, F., van der Spoel, E., Cobbaert, C. M., Ballieux, B. E., Egri, P., Kvarta-Papp, Z., Gereben, B., Fekete, C., Slagboom, P. E., van der Grond, J., Demeneix, B. A., Pijl, H., Westendorp, R. GJ., & van Heemst, D. (2015). Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. Scientific Reports, 5, [11525 ]. https://doi.org/10.1038/srep11525

Vancouver

Jansen SW, Akintola AA, Roelfsema F, van der Spoel E, Cobbaert CM, Ballieux BE et al. Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. Scientific Reports. 2015;5. 11525 . https://doi.org/10.1038/srep11525

Author

Jansen, S W ; Akintola, A A ; Roelfsema, F ; van der Spoel, E ; Cobbaert, C M ; Ballieux, B E ; Egri, P ; Kvarta-Papp, Z ; Gereben, B ; Fekete, C ; Slagboom, P E ; van der Grond, J ; Demeneix, B A ; Pijl, H ; Westendorp, Rudi GJ ; van Heemst, D. / Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. In: Scientific Reports. 2015 ; Vol. 5.

Bibtex

@article{c927e7a43ce740939561feef23118771,
title = "Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism",
abstract = "Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hormone (TH) in an inverse relationship. Greater longevity has been associated with higher TSH and lower TH levels, but mechanisms underlying TSH/TH differences and longevity remain unknown. The HPT axis plays a pivotal role in growth, development and energy metabolism. We report that offspring of nonagenarians with at least one nonagenarian sibling have increased TSH secretion but similar bioactivity of TSH and similar TH levels compared to controls. Healthy offspring and spousal controls had similar resting metabolic rate and core body temperature. We propose that pleiotropic effects of the HPT axis may favour longevity without altering energy metabolism.",
author = "Jansen, {S W} and Akintola, {A A} and F Roelfsema and {van der Spoel}, E and Cobbaert, {C M} and Ballieux, {B E} and P Egri and Z Kvarta-Papp and B Gereben and C Fekete and Slagboom, {P E} and {van der Grond}, J and Demeneix, {B A} and H Pijl and Westendorp, {Rudi GJ} and {van Heemst}, D",
year = "2015",
doi = "10.1038/srep11525",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

AU - Jansen, S W

AU - Akintola, A A

AU - Roelfsema, F

AU - van der Spoel, E

AU - Cobbaert, C M

AU - Ballieux, B E

AU - Egri, P

AU - Kvarta-Papp, Z

AU - Gereben, B

AU - Fekete, C

AU - Slagboom, P E

AU - van der Grond, J

AU - Demeneix, B A

AU - Pijl, H

AU - Westendorp, Rudi GJ

AU - van Heemst, D

PY - 2015

Y1 - 2015

N2 - Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hormone (TH) in an inverse relationship. Greater longevity has been associated with higher TSH and lower TH levels, but mechanisms underlying TSH/TH differences and longevity remain unknown. The HPT axis plays a pivotal role in growth, development and energy metabolism. We report that offspring of nonagenarians with at least one nonagenarian sibling have increased TSH secretion but similar bioactivity of TSH and similar TH levels compared to controls. Healthy offspring and spousal controls had similar resting metabolic rate and core body temperature. We propose that pleiotropic effects of the HPT axis may favour longevity without altering energy metabolism.

AB - Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hormone (TH) in an inverse relationship. Greater longevity has been associated with higher TSH and lower TH levels, but mechanisms underlying TSH/TH differences and longevity remain unknown. The HPT axis plays a pivotal role in growth, development and energy metabolism. We report that offspring of nonagenarians with at least one nonagenarian sibling have increased TSH secretion but similar bioactivity of TSH and similar TH levels compared to controls. Healthy offspring and spousal controls had similar resting metabolic rate and core body temperature. We propose that pleiotropic effects of the HPT axis may favour longevity without altering energy metabolism.

U2 - 10.1038/srep11525

DO - 10.1038/srep11525

M3 - Journal article

C2 - 26089239

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 11525

ER -

ID: 140392285