Homogeneous nucleation of hydroxyapatite, ca5oh(Po4)3, at 37c

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Precipitation of the calcium phosphate hydroxyapatite, Ca5OH(PO4 )3, is studied by simple mixing of reagent solutions and measurement of light scattering (turbidimetry) at six different wavelengths from 300 to 800 nm. Measured turbidities are analyzed using Mie’s theory of light scattering from small particles. Results are interpreted in terms of classical theory of homogeneous nucleation, and from this the surface free energy of crystals is determined. The low value thus found is explained as the effect of protonation of the strongly basic anions hydroxide and phosphate at the crystal surface. Relatively large particles registered by turbidimetry are shown to be not monocrystals, but aggregates of nanocrystals.

Original languageEnglish
Article number695
Issue number8
Number of pages8
Publication statusPublished - 2020

Bibliographical note

Publisher Copyright:
© 2020 by the author. Licensee MDPI, Basel, Switzerland.

    Research areas

  • Calcium phosphate, Homogeneous nucleation, Hydroxyapatite, Light scattering, Surface free energy, Surface protonation

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