High-Throughput Fabrication of Nanocomplexes Using 3D-Printed Micromixers

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

High-Throughput Fabrication of Nanocomplexes Using 3D-Printed Micromixers. / Bohr, Adam; Boetker, Johan; Wang, Yingya; Jensen, Henrik; Rantanen, Jukka; Beck-Broichsitter, Moritz.

In: Journal of Pharmaceutical Sciences, Vol. 106, No. 3, 2017, p. 835-842.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bohr, A, Boetker, J, Wang, Y, Jensen, H, Rantanen, J & Beck-Broichsitter, M 2017, 'High-Throughput Fabrication of Nanocomplexes Using 3D-Printed Micromixers', Journal of Pharmaceutical Sciences, vol. 106, no. 3, pp. 835-842. https://doi.org/10.1016/j.xphs.2016.10.027

APA

Bohr, A., Boetker, J., Wang, Y., Jensen, H., Rantanen, J., & Beck-Broichsitter, M. (2017). High-Throughput Fabrication of Nanocomplexes Using 3D-Printed Micromixers. Journal of Pharmaceutical Sciences, 106(3), 835-842. https://doi.org/10.1016/j.xphs.2016.10.027

Vancouver

Bohr A, Boetker J, Wang Y, Jensen H, Rantanen J, Beck-Broichsitter M. High-Throughput Fabrication of Nanocomplexes Using 3D-Printed Micromixers. Journal of Pharmaceutical Sciences. 2017;106(3):835-842. https://doi.org/10.1016/j.xphs.2016.10.027

Author

Bohr, Adam ; Boetker, Johan ; Wang, Yingya ; Jensen, Henrik ; Rantanen, Jukka ; Beck-Broichsitter, Moritz. / High-Throughput Fabrication of Nanocomplexes Using 3D-Printed Micromixers. In: Journal of Pharmaceutical Sciences. 2017 ; Vol. 106, No. 3. pp. 835-842.

Bibtex

@article{2440b1bcc53349778db701193da27298,

title = "High-Throughput Fabrication of Nanocomplexes Using 3D-Printed Micromixers",

abstract = "3D printing allows a rapid and inexpensive manufacturing of custom made and prototype devices. Micromixers are used for rapid and controlled production of nanoparticles intended for therapeutic delivery. In this study, we demonstrate the fabrication of micromixers using computational design and 3D printing, which enable a continuous and industrial scale production of nanocomplexes formed by electrostatic complexation, using the polymers poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate). Several parameters including polymer concentration, flow rate, and flow ratio were systematically varied and their effect on the properties of nanocomplexes was studied and compared with nanocomplexes prepared by bulk mixing. Particles fabricated using this cost effective device were equally small and homogenous but more consistent and controllable in size compared with those prepared manually via bulk mixing. Moreover, each micromixer could process more than 2 liters per hour with unaffected performance and the setup could easily be scaled-up by aligning several micromixers in parallel. This demonstrates that 3D printing can be used to prepare disposable high-throughput micromixers for production of therapeutic nanoparticles.",

author = "Adam Bohr and Johan Boetker and Yingya Wang and Henrik Jensen and Jukka Rantanen and Moritz Beck-Broichsitter",

year = "2017",

doi = "10.1016/j.xphs.2016.10.027",

language = "English",

volume = "106",

pages = "835--842",

journal = "Journal of Pharmaceutical Sciences",

issn = "0022-3549",

publisher = "Elsevier",

number = "3",

}

RIS

TY - JOUR

T1 - High-Throughput Fabrication of Nanocomplexes Using 3D-Printed Micromixers

AU - Bohr, Adam

AU - Boetker, Johan

AU - Wang, Yingya

AU - Jensen, Henrik

AU - Rantanen, Jukka

AU - Beck-Broichsitter, Moritz

PY - 2017

Y1 - 2017

N2 - 3D printing allows a rapid and inexpensive manufacturing of custom made and prototype devices. Micromixers are used for rapid and controlled production of nanoparticles intended for therapeutic delivery. In this study, we demonstrate the fabrication of micromixers using computational design and 3D printing, which enable a continuous and industrial scale production of nanocomplexes formed by electrostatic complexation, using the polymers poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate). Several parameters including polymer concentration, flow rate, and flow ratio were systematically varied and their effect on the properties of nanocomplexes was studied and compared with nanocomplexes prepared by bulk mixing. Particles fabricated using this cost effective device were equally small and homogenous but more consistent and controllable in size compared with those prepared manually via bulk mixing. Moreover, each micromixer could process more than 2 liters per hour with unaffected performance and the setup could easily be scaled-up by aligning several micromixers in parallel. This demonstrates that 3D printing can be used to prepare disposable high-throughput micromixers for production of therapeutic nanoparticles.

AB - 3D printing allows a rapid and inexpensive manufacturing of custom made and prototype devices. Micromixers are used for rapid and controlled production of nanoparticles intended for therapeutic delivery. In this study, we demonstrate the fabrication of micromixers using computational design and 3D printing, which enable a continuous and industrial scale production of nanocomplexes formed by electrostatic complexation, using the polymers poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate). Several parameters including polymer concentration, flow rate, and flow ratio were systematically varied and their effect on the properties of nanocomplexes was studied and compared with nanocomplexes prepared by bulk mixing. Particles fabricated using this cost effective device were equally small and homogenous but more consistent and controllable in size compared with those prepared manually via bulk mixing. Moreover, each micromixer could process more than 2 liters per hour with unaffected performance and the setup could easily be scaled-up by aligning several micromixers in parallel. This demonstrates that 3D printing can be used to prepare disposable high-throughput micromixers for production of therapeutic nanoparticles.

U2 - 10.1016/j.xphs.2016.10.027

DO - 10.1016/j.xphs.2016.10.027

M3 - Journal article

C2 - 27938892

VL - 106

SP - 835

EP - 842

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 3

ER -

ID: 170703116