Ethane and n-pentane in exhaled breath are biomarkers of exposure not effect

Research output: Contribution to journalJournal articleResearchpeer-review

The relationship of exhaled ethane and n-pentane to exhaled NO, carbonylated proteins, and indoor/outdoor atmospheric pollutants were examined in order to evaluate ethane and n-pentane as potential markers of airway inflammation and/or oxidative stress. Exhaled NO and carbonylated proteins were found to have no significant associations with either ethane (p = 0.96 and p = 0.81, respectively) or n-pentane (p = 0.44 and 0.28, respectively) when outliers were included. In the case where outliers were removed n-pentane was found to be inversely associated with carbonylated proteins. Exhaled hydrocarbons adjusted for indoor hydrocarbon concentrations were instead found to be positively associated with air pollutants (NO, NO(2) and CO), suggesting pollutant exposure is driving exhaled hydrocarbon concentrations. Given these findings, ethane and n-pentane do not appear to be markers of airway inflammation or oxidative stress.
Original languageEnglish
Issue number1
Pages (from-to)17-25
Number of pages9
Publication statusPublished - 2009

    Research areas

  • Aged, Aged, 80 and over, Biological Markers, Breath Tests, Ethane, Female, Humans, Male, Pentanes

ID: 44565349