Drug delivery by phospholipase A2 degradable liposomes

Research output: Contribution to journalJournal articleResearchpeer-review

The effect of poly(ethylene glycol)-phospholipid (PE-PEG) lipopolymers on phospholipase A2 (PLA2) hydrolysis of liposomes composed of stearoyl-oleoylphosphatidylcholine (SOPC) was investigated. The PLA2 lag-time, which is inversely related to the enzymatic activity, was determined by fluorescence, and the zeta-potentials of the liposomes were measured as a function of PE-PEG lipopolymer concentration. A significant decrease in the lag-time, and hence an increase in enzymatic activity, was observed with increasing amounts of the negatively charged PE-PEG lipopolymers incorporated into the SOPC liposomes. The enhancement of the PLA2 enzymatic activity might involve a stronger PLA2 binding affinity towards the negatively charged and polymer covered PEG liposomes.

Original languageEnglish
JournalInternational Journal of Pharmaceutics
Issue number1-2
Pages (from-to)67-69
Number of pages3
Publication statusPublished - 19 Feb 2001

    Research areas

  • Degradation, Drug-delivery, Lipopolymer, Liposomes, PEG liposomes, Phospholipase A

ID: 230987712