Dissolution study of nanocrystal powders of a poorly soluble drug by UV imaging and channel flow methods

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Dissolution study of nanocrystal powders of a poorly soluble drug by UV imaging and channel flow methods. / Sarnes, Annika; Østergaard, Jesper; Jensen, Sabrine Smedegaard; Aaltonen, Jaakko; Rantanen, Jukka; Hirvonen, Jouni; Peltonen, Leena.

In: European Journal of Pharmaceutical Sciences, Vol. 50, No. 3-4, 20.11.2013, p. 511-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sarnes, A, Østergaard, J, Jensen, SS, Aaltonen, J, Rantanen, J, Hirvonen, J & Peltonen, L 2013, 'Dissolution study of nanocrystal powders of a poorly soluble drug by UV imaging and channel flow methods', European Journal of Pharmaceutical Sciences, vol. 50, no. 3-4, pp. 511-9. https://doi.org/10.1016/j.ejps.2013.08.030

APA

Sarnes, A., Østergaard, J., Jensen, S. S., Aaltonen, J., Rantanen, J., Hirvonen, J., & Peltonen, L. (2013). Dissolution study of nanocrystal powders of a poorly soluble drug by UV imaging and channel flow methods. European Journal of Pharmaceutical Sciences, 50(3-4), 511-9. https://doi.org/10.1016/j.ejps.2013.08.030

Vancouver

Sarnes A, Østergaard J, Jensen SS, Aaltonen J, Rantanen J, Hirvonen J et al. Dissolution study of nanocrystal powders of a poorly soluble drug by UV imaging and channel flow methods. European Journal of Pharmaceutical Sciences. 2013 Nov 20;50(3-4):511-9. https://doi.org/10.1016/j.ejps.2013.08.030

Author

Sarnes, Annika ; Østergaard, Jesper ; Jensen, Sabrine Smedegaard ; Aaltonen, Jaakko ; Rantanen, Jukka ; Hirvonen, Jouni ; Peltonen, Leena. / Dissolution study of nanocrystal powders of a poorly soluble drug by UV imaging and channel flow methods. In: European Journal of Pharmaceutical Sciences. 2013 ; Vol. 50, No. 3-4. pp. 511-9.

Bibtex

@article{9cee10fe7433450784a453d9e94fdae9,

title = "Dissolution study of nanocrystal powders of a poorly soluble drug by UV imaging and channel flow methods",

abstract = "Application of drug nanocrystals provides advantageous options for the pharmaceutical formulation development of poorly soluble drugs. The objective of this study was to investigate the dissolution behavior improving effects of differently sized nanocrystals of a poorly soluble model drug, indomethacin. Nanocrystal suspensions were prepared using a top-down wet milling technique with three stabilizers: poloxamer F68, poloxamer F127 and polysorbate 80. The dissolution of the differently sized indomethacin nanocrystals were investigated using a channel flow dissolution method and by UV imaging. Unmilled bulk indomethacin and physical mixtures were used as references. According to both the dissolution methods, the dissolution properties of indomethacin were improved by the particle size reduction. UV imaging was used for the first time as a dissolution testing method for fast dissolving nanoscale material. The technique provided new information about the concentration of the dissolved drug next to the sample surface; with the smallest nanocrystals (580 nm) the indomethacin concentration next to the particle surface exceeded five-fold the thermodynamic saturated indomethacin solution concentration. Thus the solubility improvement itself, not only the increased surface area for dissolution, may have an important role in the higher dissolution rates of nanocrystal formulations. Poloxamer F68 was the most optimal stabilizer in the preparation of the indomethacin nanocrystal suspensions and in the solubility and dissolution enhancement as well.",

author = "Annika Sarnes and Jesper {\O}stergaard and Jensen, {Sabrine Smedegaard} and Jaakko Aaltonen and Jukka Rantanen and Jouni Hirvonen and Leena Peltonen",

year = "2013",

month = nov,

day = "20",

doi = "10.1016/j.ejps.2013.08.030",

language = "English",

volume = "50",

pages = "511--9",

journal = "Norvegica Pharmaceutica Acta",

issn = "0928-0987",

publisher = "Elsevier",

number = "3-4",

}

RIS

TY - JOUR

T1 - Dissolution study of nanocrystal powders of a poorly soluble drug by UV imaging and channel flow methods

AU - Sarnes, Annika

AU - Østergaard, Jesper

AU - Jensen, Sabrine Smedegaard

AU - Aaltonen, Jaakko

AU - Rantanen, Jukka

AU - Hirvonen, Jouni

AU - Peltonen, Leena

PY - 2013/11/20

Y1 - 2013/11/20

N2 - Application of drug nanocrystals provides advantageous options for the pharmaceutical formulation development of poorly soluble drugs. The objective of this study was to investigate the dissolution behavior improving effects of differently sized nanocrystals of a poorly soluble model drug, indomethacin. Nanocrystal suspensions were prepared using a top-down wet milling technique with three stabilizers: poloxamer F68, poloxamer F127 and polysorbate 80. The dissolution of the differently sized indomethacin nanocrystals were investigated using a channel flow dissolution method and by UV imaging. Unmilled bulk indomethacin and physical mixtures were used as references. According to both the dissolution methods, the dissolution properties of indomethacin were improved by the particle size reduction. UV imaging was used for the first time as a dissolution testing method for fast dissolving nanoscale material. The technique provided new information about the concentration of the dissolved drug next to the sample surface; with the smallest nanocrystals (580 nm) the indomethacin concentration next to the particle surface exceeded five-fold the thermodynamic saturated indomethacin solution concentration. Thus the solubility improvement itself, not only the increased surface area for dissolution, may have an important role in the higher dissolution rates of nanocrystal formulations. Poloxamer F68 was the most optimal stabilizer in the preparation of the indomethacin nanocrystal suspensions and in the solubility and dissolution enhancement as well.

AB - Application of drug nanocrystals provides advantageous options for the pharmaceutical formulation development of poorly soluble drugs. The objective of this study was to investigate the dissolution behavior improving effects of differently sized nanocrystals of a poorly soluble model drug, indomethacin. Nanocrystal suspensions were prepared using a top-down wet milling technique with three stabilizers: poloxamer F68, poloxamer F127 and polysorbate 80. The dissolution of the differently sized indomethacin nanocrystals were investigated using a channel flow dissolution method and by UV imaging. Unmilled bulk indomethacin and physical mixtures were used as references. According to both the dissolution methods, the dissolution properties of indomethacin were improved by the particle size reduction. UV imaging was used for the first time as a dissolution testing method for fast dissolving nanoscale material. The technique provided new information about the concentration of the dissolved drug next to the sample surface; with the smallest nanocrystals (580 nm) the indomethacin concentration next to the particle surface exceeded five-fold the thermodynamic saturated indomethacin solution concentration. Thus the solubility improvement itself, not only the increased surface area for dissolution, may have an important role in the higher dissolution rates of nanocrystal formulations. Poloxamer F68 was the most optimal stabilizer in the preparation of the indomethacin nanocrystal suspensions and in the solubility and dissolution enhancement as well.

U2 - 10.1016/j.ejps.2013.08.030

DO - 10.1016/j.ejps.2013.08.030

M3 - Journal article

C2 - 23999036

VL - 50

SP - 511

EP - 519

JO - Norvegica Pharmaceutica Acta

JF - Norvegica Pharmaceutica Acta

SN - 0928-0987

IS - 3-4

ER -

ID: 104835512