C-Terminal lactamization of peptides

Research output: Contribution to journalJournal articleResearchpeer-review

Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or ε-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides.
Original languageEnglish
JournalChemical Communications
Issue number7
Pages (from-to)895-898
Number of pages4
Publication statusPublished - 2021

ID: 261160414