Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation

Research output: Contribution to journalReviewResearchpeer-review

Inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury. In some disorders, the inflammatory process - which under normal conditions is self-limiting - becomes continuous and chronic inflammatory diseases might develop subsequently. Pattern recognition molecules (PRMs) represent a diverse collection of molecules responsible for sensing danger signals, and together with other immune components they are involved in the first line of defence. NALP3 and NOD2, which belong to a cytosolic subgroup of PRMs, dubbed Nod-like-receptors (NLRs), have been associated recently with inflammatory diseases, specifically Crohn's disease and Blau syndrome (NOD2) and familial cold autoinflammatory syndrome, Muckle-Wells syndrome and chronic infantile neurological cutaneous and articular syndrome (NALP3). The exact effects of the defective proteins are not fully understood, but activation of nuclear factor (NF)-kappaB, transcription, production and secretion of interleukin (IL)-1beta and activation of the inflammasome are some of the processes that might hold clues, and the present review will provide a thorough update in this area.

Original languageEnglish
JournalClinical and Experimental Immunology
Issue number2
Pages (from-to)227-35
Number of pages9
Publication statusPublished - Feb 2007

    Research areas

  • Carrier Proteins/immunology, Chronic Disease, Crohn Disease/immunology, Humans, Inflammation/immunology, Interleukin-1beta/biosynthesis, NLR Family, Pyrin Domain-Containing 3 Protein, Nod2 Signaling Adaptor Protein/immunology, Signal Transduction/immunology

ID: 222543359