Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. / Rizwan, Shakila B; Boyd, Ben J; Rades, Thomas; Hook, Sarah.

In: Expert Opinion on Drug Delivery, Vol. 7, No. 10, 2010, p. 1133-44.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rizwan, SB, Boyd, BJ, Rades, T & Hook, S 2010, 'Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins', Expert Opinion on Drug Delivery, vol. 7, no. 10, pp. 1133-44. https://doi.org/10.1517/17425247.2010.515584

APA

Rizwan, S. B., Boyd, B. J., Rades, T., & Hook, S. (2010). Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. Expert Opinion on Drug Delivery, 7(10), 1133-44. https://doi.org/10.1517/17425247.2010.515584

Vancouver

Rizwan SB, Boyd BJ, Rades T, Hook S. Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. Expert Opinion on Drug Delivery. 2010;7(10):1133-44. https://doi.org/10.1517/17425247.2010.515584

Author

Rizwan, Shakila B ; Boyd, Ben J ; Rades, Thomas ; Hook, Sarah. / Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. In: Expert Opinion on Drug Delivery. 2010 ; Vol. 7, No. 10. pp. 1133-44.

Bibtex

@article{bd266cfbd4b84db0860e6433e2177a25,
title = "Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins",
abstract = "Self-assembling lipid-based liquid crystalline systems are a broad and active area of research. Of these mesophases, the cubic phase with its highly twisted bilayer and two non-intersecting water channels has been investigated extensively for drug delivery. The cubic phase has been shown to accommodate and control the release of drugs with varying physicochemical properties. Also, the lipids used to prepare these delivery systems are generally cheap, safe and biodegradable, making these systems highly attractive. Early research investigating the potential of cubic phases as delivery systems showed that several peptides or proteins entrapped within these gel-based systems showed retarded release. Furthermore, entrapment within the cubic phase protected the selected peptide or protein from chemical and physical degradation with its native confirmation and bioactivity retained.",
author = "Rizwan, {Shakila B} and Boyd, {Ben J} and Thomas Rades and Sarah Hook",
year = "2010",
doi = "10.1517/17425247.2010.515584",
language = "English",
volume = "7",
pages = "1133--44",
journal = "Expert Opinion on Drug Delivery",
issn = "1742-5247",
publisher = "Taylor & Francis",
number = "10",

}

RIS

TY - JOUR

T1 - Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins

AU - Rizwan, Shakila B

AU - Boyd, Ben J

AU - Rades, Thomas

AU - Hook, Sarah

PY - 2010

Y1 - 2010

N2 - Self-assembling lipid-based liquid crystalline systems are a broad and active area of research. Of these mesophases, the cubic phase with its highly twisted bilayer and two non-intersecting water channels has been investigated extensively for drug delivery. The cubic phase has been shown to accommodate and control the release of drugs with varying physicochemical properties. Also, the lipids used to prepare these delivery systems are generally cheap, safe and biodegradable, making these systems highly attractive. Early research investigating the potential of cubic phases as delivery systems showed that several peptides or proteins entrapped within these gel-based systems showed retarded release. Furthermore, entrapment within the cubic phase protected the selected peptide or protein from chemical and physical degradation with its native confirmation and bioactivity retained.

AB - Self-assembling lipid-based liquid crystalline systems are a broad and active area of research. Of these mesophases, the cubic phase with its highly twisted bilayer and two non-intersecting water channels has been investigated extensively for drug delivery. The cubic phase has been shown to accommodate and control the release of drugs with varying physicochemical properties. Also, the lipids used to prepare these delivery systems are generally cheap, safe and biodegradable, making these systems highly attractive. Early research investigating the potential of cubic phases as delivery systems showed that several peptides or proteins entrapped within these gel-based systems showed retarded release. Furthermore, entrapment within the cubic phase protected the selected peptide or protein from chemical and physical degradation with its native confirmation and bioactivity retained.

U2 - 10.1517/17425247.2010.515584

DO - 10.1517/17425247.2010.515584

M3 - Journal article

C2 - 20858165

VL - 7

SP - 1133

EP - 1144

JO - Expert Opinion on Drug Delivery

JF - Expert Opinion on Drug Delivery

SN - 1742-5247

IS - 10

ER -

ID: 40343705