Azotides as Modular Peptide-Based Ligands for Asymmetric Lewis Acid Catalysis

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Synthesis of azotides and evaluation of these as ligands for enantioselective Lewis acid catalysis is reported. The ligands were readily prepared from the chiral pool of amino acids and perform well in the cobalt(II)-catalyzed formation of asymmetric hetero Diels-Alder adducts. A rational for the observed enantioselectivity and conversion rate supported by computational calculations is provided.

Original languageEnglish
JournalJournal of Organic Chemistry
Issue number11
Pages (from-to)6940-6945
Number of pages6
Publication statusPublished - 7 Jun 2019

ID: 231361334