Asthma-like symptoms in young children increase the risk of COPD
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Asthma-like symptoms in young children increase the risk of COPD. / Bisgaard, Hans; Nørgaard, Sarah; Sevelsted, Astrid; Chawes, Bo Lund; Stokholm, Jakob; Mortensen, Erik Lykke; Ulrik, Charlotte Suppli; Bønnelykke, Klaus.
In: Journal of Allergy and Clinical Immunology, Vol. 147, No. 2, 2021, p. 569-576.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Asthma-like symptoms in young children increase the risk of COPD
AU - Bisgaard, Hans
AU - Nørgaard, Sarah
AU - Sevelsted, Astrid
AU - Chawes, Bo Lund
AU - Stokholm, Jakob
AU - Mortensen, Erik Lykke
AU - Ulrik, Charlotte Suppli
AU - Bønnelykke, Klaus
PY - 2021
Y1 - 2021
N2 - Background: Chronic obstructive pulmonary disease (COPD) may originate in early life and share disease mechanisms with asthma-like symptoms in early childhood. This possibility remains unexplored on account of the lack of long-term prospective studies from infancy to the onset of COPD. Objective: We aimed to investigate the relationship between asthma-like symptoms in young children and development of COPD. Methods: In a population-based cohort of women who gave birth at the central hospital in Copenhagen during period from 1959 to 1961, we investigated data from 3290 mother-child pairs who attended examinations during pregnancy and when the children were aged 1, 3, and 6 years. COPD was assessed from the Danish national registries on hospitalizations and prescription medication since 1994. A subgroup of 930 individuals underwent spirometry testing at age 50 years. Results: Of the 3290 children, 1 in 4 had a history of asthma-like symptoms in early childhood. The adjusted hazard ratio for hospitalization for COPD was 1.88 (95% CI = 1.32-2.68), and the odds ratio for prescription of long-acting muscarinic antagonists was 2.27 (95% CI = 1.38-3.70). Asthma-like symptoms in early childhood were also associated with a reduced FEV1 percent predicted and an FEV1-to–forced vital capacity ratio at age 50 years (–3.36% [95% CI = –5.47 to –1.24] and –1.28 [95% CI = –2.17 to –0.38], respectively) and with COPD defined according to Global Initiative for Chronic Obstructive Lung Disease stage higher than 1 (odds ratio = 1.96 [95% CI = 1.13-3.34]). Conclusion: This 60-year prospective follow-up of a mother-child cohort demonstrated a doubled risk for COPD from childhood asthma-like symptoms.
AB - Background: Chronic obstructive pulmonary disease (COPD) may originate in early life and share disease mechanisms with asthma-like symptoms in early childhood. This possibility remains unexplored on account of the lack of long-term prospective studies from infancy to the onset of COPD. Objective: We aimed to investigate the relationship between asthma-like symptoms in young children and development of COPD. Methods: In a population-based cohort of women who gave birth at the central hospital in Copenhagen during period from 1959 to 1961, we investigated data from 3290 mother-child pairs who attended examinations during pregnancy and when the children were aged 1, 3, and 6 years. COPD was assessed from the Danish national registries on hospitalizations and prescription medication since 1994. A subgroup of 930 individuals underwent spirometry testing at age 50 years. Results: Of the 3290 children, 1 in 4 had a history of asthma-like symptoms in early childhood. The adjusted hazard ratio for hospitalization for COPD was 1.88 (95% CI = 1.32-2.68), and the odds ratio for prescription of long-acting muscarinic antagonists was 2.27 (95% CI = 1.38-3.70). Asthma-like symptoms in early childhood were also associated with a reduced FEV1 percent predicted and an FEV1-to–forced vital capacity ratio at age 50 years (–3.36% [95% CI = –5.47 to –1.24] and –1.28 [95% CI = –2.17 to –0.38], respectively) and with COPD defined according to Global Initiative for Chronic Obstructive Lung Disease stage higher than 1 (odds ratio = 1.96 [95% CI = 1.13-3.34]). Conclusion: This 60-year prospective follow-up of a mother-child cohort demonstrated a doubled risk for COPD from childhood asthma-like symptoms.
KW - Asthma
KW - cohort study
KW - COPD
U2 - 10.1016/j.jaci.2020.05.043
DO - 10.1016/j.jaci.2020.05.043
M3 - Journal article
C2 - 32535134
AN - SCOPUS:85089463413
VL - 147
SP - 569
EP - 576
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 2
ER -
ID: 257972898