Asthma-like symptoms in young children increase the risk of COPD

Research output: Contribution to journalJournal articlepeer-review

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Asthma-like symptoms in young children increase the risk of COPD. / Bisgaard, Hans; Nørgaard, Sarah; Sevelsted, Astrid; Chawes, Bo Lund; Stokholm, Jakob; Mortensen, Erik Lykke; Ulrik, Charlotte Suppli; Bønnelykke, Klaus.

In: Journal of Allergy and Clinical Immunology, Vol. 147, No. 2, 2021, p. 569-576.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Bisgaard, H, Nørgaard, S, Sevelsted, A, Chawes, BL, Stokholm, J, Mortensen, EL, Ulrik, CS & Bønnelykke, K 2021, 'Asthma-like symptoms in young children increase the risk of COPD', Journal of Allergy and Clinical Immunology, vol. 147, no. 2, pp. 569-576. https://doi.org/10.1016/j.jaci.2020.05.043

APA

Bisgaard, H., Nørgaard, S., Sevelsted, A., Chawes, B. L., Stokholm, J., Mortensen, E. L., Ulrik, C. S., & Bønnelykke, K. (2021). Asthma-like symptoms in young children increase the risk of COPD. Journal of Allergy and Clinical Immunology, 147(2), 569-576. https://doi.org/10.1016/j.jaci.2020.05.043

Vancouver

Bisgaard H, Nørgaard S, Sevelsted A, Chawes BL, Stokholm J, Mortensen EL et al. Asthma-like symptoms in young children increase the risk of COPD. Journal of Allergy and Clinical Immunology. 2021;147(2):569-576. https://doi.org/10.1016/j.jaci.2020.05.043

Author

Bisgaard, Hans ; Nørgaard, Sarah ; Sevelsted, Astrid ; Chawes, Bo Lund ; Stokholm, Jakob ; Mortensen, Erik Lykke ; Ulrik, Charlotte Suppli ; Bønnelykke, Klaus. / Asthma-like symptoms in young children increase the risk of COPD. In: Journal of Allergy and Clinical Immunology. 2021 ; Vol. 147, No. 2. pp. 569-576.

Bibtex

@article{78326fd7338240c8b6a19a0fb97530d8,
title = "Asthma-like symptoms in young children increase the risk of COPD",
abstract = "Background: Chronic obstructive pulmonary disease (COPD) may originate in early life and share disease mechanisms with asthma-like symptoms in early childhood. This possibility remains unexplored on account of the lack of long-term prospective studies from infancy to the onset of COPD. Objective: We aimed to investigate the relationship between asthma-like symptoms in young children and development of COPD. Methods: In a population-based cohort of women who gave birth at the central hospital in Copenhagen during period from 1959 to 1961, we investigated data from 3290 mother-child pairs who attended examinations during pregnancy and when the children were aged 1, 3, and 6 years. COPD was assessed from the Danish national registries on hospitalizations and prescription medication since 1994. A subgroup of 930 individuals underwent spirometry testing at age 50 years. Results: Of the 3290 children, 1 in 4 had a history of asthma-like symptoms in early childhood. The adjusted hazard ratio for hospitalization for COPD was 1.88 (95% CI = 1.32-2.68), and the odds ratio for prescription of long-acting muscarinic antagonists was 2.27 (95% CI = 1.38-3.70). Asthma-like symptoms in early childhood were also associated with a reduced FEV1 percent predicted and an FEV1-to–forced vital capacity ratio at age 50 years (–3.36% [95% CI = –5.47 to –1.24] and –1.28 [95% CI = –2.17 to –0.38], respectively) and with COPD defined according to Global Initiative for Chronic Obstructive Lung Disease stage higher than 1 (odds ratio = 1.96 [95% CI = 1.13-3.34]). Conclusion: This 60-year prospective follow-up of a mother-child cohort demonstrated a doubled risk for COPD from childhood asthma-like symptoms.",
keywords = "Asthma, cohort study, COPD",
author = "Hans Bisgaard and Sarah N{\o}rgaard and Astrid Sevelsted and Chawes, {Bo Lund} and Jakob Stokholm and Mortensen, {Erik Lykke} and Ulrik, {Charlotte Suppli} and Klaus B{\o}nnelykke",
year = "2021",
doi = "10.1016/j.jaci.2020.05.043",
language = "English",
volume = "147",
pages = "569--576",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Asthma-like symptoms in young children increase the risk of COPD

AU - Bisgaard, Hans

AU - Nørgaard, Sarah

AU - Sevelsted, Astrid

AU - Chawes, Bo Lund

AU - Stokholm, Jakob

AU - Mortensen, Erik Lykke

AU - Ulrik, Charlotte Suppli

AU - Bønnelykke, Klaus

PY - 2021

Y1 - 2021

N2 - Background: Chronic obstructive pulmonary disease (COPD) may originate in early life and share disease mechanisms with asthma-like symptoms in early childhood. This possibility remains unexplored on account of the lack of long-term prospective studies from infancy to the onset of COPD. Objective: We aimed to investigate the relationship between asthma-like symptoms in young children and development of COPD. Methods: In a population-based cohort of women who gave birth at the central hospital in Copenhagen during period from 1959 to 1961, we investigated data from 3290 mother-child pairs who attended examinations during pregnancy and when the children were aged 1, 3, and 6 years. COPD was assessed from the Danish national registries on hospitalizations and prescription medication since 1994. A subgroup of 930 individuals underwent spirometry testing at age 50 years. Results: Of the 3290 children, 1 in 4 had a history of asthma-like symptoms in early childhood. The adjusted hazard ratio for hospitalization for COPD was 1.88 (95% CI = 1.32-2.68), and the odds ratio for prescription of long-acting muscarinic antagonists was 2.27 (95% CI = 1.38-3.70). Asthma-like symptoms in early childhood were also associated with a reduced FEV1 percent predicted and an FEV1-to–forced vital capacity ratio at age 50 years (–3.36% [95% CI = –5.47 to –1.24] and –1.28 [95% CI = –2.17 to –0.38], respectively) and with COPD defined according to Global Initiative for Chronic Obstructive Lung Disease stage higher than 1 (odds ratio = 1.96 [95% CI = 1.13-3.34]). Conclusion: This 60-year prospective follow-up of a mother-child cohort demonstrated a doubled risk for COPD from childhood asthma-like symptoms.

AB - Background: Chronic obstructive pulmonary disease (COPD) may originate in early life and share disease mechanisms with asthma-like symptoms in early childhood. This possibility remains unexplored on account of the lack of long-term prospective studies from infancy to the onset of COPD. Objective: We aimed to investigate the relationship between asthma-like symptoms in young children and development of COPD. Methods: In a population-based cohort of women who gave birth at the central hospital in Copenhagen during period from 1959 to 1961, we investigated data from 3290 mother-child pairs who attended examinations during pregnancy and when the children were aged 1, 3, and 6 years. COPD was assessed from the Danish national registries on hospitalizations and prescription medication since 1994. A subgroup of 930 individuals underwent spirometry testing at age 50 years. Results: Of the 3290 children, 1 in 4 had a history of asthma-like symptoms in early childhood. The adjusted hazard ratio for hospitalization for COPD was 1.88 (95% CI = 1.32-2.68), and the odds ratio for prescription of long-acting muscarinic antagonists was 2.27 (95% CI = 1.38-3.70). Asthma-like symptoms in early childhood were also associated with a reduced FEV1 percent predicted and an FEV1-to–forced vital capacity ratio at age 50 years (–3.36% [95% CI = –5.47 to –1.24] and –1.28 [95% CI = –2.17 to –0.38], respectively) and with COPD defined according to Global Initiative for Chronic Obstructive Lung Disease stage higher than 1 (odds ratio = 1.96 [95% CI = 1.13-3.34]). Conclusion: This 60-year prospective follow-up of a mother-child cohort demonstrated a doubled risk for COPD from childhood asthma-like symptoms.

KW - Asthma

KW - cohort study

KW - COPD

U2 - 10.1016/j.jaci.2020.05.043

DO - 10.1016/j.jaci.2020.05.043

M3 - Journal article

C2 - 32535134

AN - SCOPUS:85089463413

VL - 147

SP - 569

EP - 576

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 2

ER -

ID: 257972898