Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imaging
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Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imaging. / Zeitler, J Axel; Shen, Yaochun; Baker, Colin; Taday, Philip F; Pepper, Michael; Rades, Thomas.
In: Journal of Pharmaceutical Sciences, Vol. 96, No. 2, 2007, p. 330-40.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imaging
AU - Zeitler, J Axel
AU - Shen, Yaochun
AU - Baker, Colin
AU - Taday, Philip F
AU - Pepper, Michael
AU - Rades, Thomas
N1 - Copyright (c) 2006 Wiley-Liss, Inc.
PY - 2007
Y1 - 2007
N2 - Three dimensional terahertz pulsed imaging (TPI) was evaluated as a novel tool for the nondestructive characterization of different solid oral dosage forms. The time-domain reflection signal of coherent pulsed light in the far infrared was used to investigate film-coated tablets, sugar-coated tablets, multilayered controlled release tablets, and soft gelatin capsules. It is possible to determine the spatial and statistical distribution of coating thickness in single and multiple coated products using 3D TPI. The measurements are nondestructive even for layers buried underneath other coating structures. The internal structure of coating materials can be analyzed. As the terahertz signal penetrates up to 3 mm into the dosage form interfaces between layers in multilayered tablets can be investigated. In soft gelatin capsules it is possible to measure the thickness of the gelatin layer and to characterize the seal between the gelatin layers for quality control. TPI is a unique approach for the nondestructive characterization and quality control of solid dosage forms. The measurements are fast and fully automated with the potential for much wider application of the technique in the process analytical technology scheme.
AB - Three dimensional terahertz pulsed imaging (TPI) was evaluated as a novel tool for the nondestructive characterization of different solid oral dosage forms. The time-domain reflection signal of coherent pulsed light in the far infrared was used to investigate film-coated tablets, sugar-coated tablets, multilayered controlled release tablets, and soft gelatin capsules. It is possible to determine the spatial and statistical distribution of coating thickness in single and multiple coated products using 3D TPI. The measurements are nondestructive even for layers buried underneath other coating structures. The internal structure of coating materials can be analyzed. As the terahertz signal penetrates up to 3 mm into the dosage form interfaces between layers in multilayered tablets can be investigated. In soft gelatin capsules it is possible to measure the thickness of the gelatin layer and to characterize the seal between the gelatin layers for quality control. TPI is a unique approach for the nondestructive characterization and quality control of solid dosage forms. The measurements are fast and fully automated with the potential for much wider application of the technique in the process analytical technology scheme.
U2 - 10.1002/jps.20789
DO - 10.1002/jps.20789
M3 - Journal article
C2 - 17075850
VL - 96
SP - 330
EP - 340
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 2
ER -
ID: 40357295