A review of recent advances in benchmark dose methodology

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In this review, recent methodological developments for the benchmark dose (BMD) methodology are summarized. Specifically, we introduce the advances for the main steps in BMD derivation: selecting the procedure for defining a BMD from a predefined benchmark response (BMR), setting a BMR, selecting a dose-response model, and estimating the corresponding BMD lower limit (BMDL). Although the last decade has shown major progress in the development of BMD methodology, there is still room for improvement. Remaining challenges are the implementation of new statistical methods in user-friendly software and the lack of consensus about how to derive the BMDL.

Original languageEnglish
JournalRisk Analysis
Issue number10
Pages (from-to)2295-2315
Number of pages21
Publication statusPublished - 2019

    Research areas

  • Faculty of Science - BMDL, Hybrid approach, Model averaging, Risk assessment, Simultaneous inference

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