A novel multiplex analysis of filaggrin polymorphisms: A universally applicable method for genotyping
Research output: Contribution to journal › Journal article › Research › peer-review
The filaggrin protein is expressed as profilaggrin mainly in stratum granulosum cells of the epidermis. The profilaggrin gene codes for 10-12 filaggrin repeats. The filaggrin protein is important for skin barrier function. Filaggrin deficiency due to functional null-polymorphisms affects 8-10% of the people in Northern Europe and is a strong risk factor for several diseases. Here, we describe a novel method for efficient, multiplexed genotyping of variations in the profilaggrin gene.
Original language | English |
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Journal | Clinica Chimica Acta |
Volume | 413 |
Issue number | 19-20 |
Pages (from-to) | 1488-92 |
Number of pages | 5 |
ISSN | 0009-8981 |
DOIs | |
Publication status | Published - 2012 |
ID: 40165585