X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices. / Kjeldsen, Rolf Bech; Kristensen, Maja Nørgaard; Gundlach, Carsten; Thamdrup, Lasse Højlund Eklund; Müllertz, Anette; Rades, Thomas; Nielsen, Line Hagner; Zór, Kinga; Boisen, Anja.

In: ACS Biomaterials Science and Engineering, Vol. 7, No. 6, 2021, p. 2538–2547.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kjeldsen, RB, Kristensen, MN, Gundlach, C, Thamdrup, LHE, Müllertz, A, Rades, T, Nielsen, LH, Zór, K & Boisen, A 2021, 'X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices', ACS Biomaterials Science and Engineering, vol. 7, no. 6, pp. 2538–2547. https://doi.org/10.1021/acsbiomaterials.1c00225

APA

Kjeldsen, R. B., Kristensen, M. N., Gundlach, C., Thamdrup, L. H. E., Müllertz, A., Rades, T., Nielsen, L. H., Zór, K., & Boisen, A. (2021). X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices. ACS Biomaterials Science and Engineering, 7(6), 2538–2547. https://doi.org/10.1021/acsbiomaterials.1c00225

Vancouver

Kjeldsen RB, Kristensen MN, Gundlach C, Thamdrup LHE, Müllertz A, Rades T et al. X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices. ACS Biomaterials Science and Engineering. 2021;7(6):2538–2547. https://doi.org/10.1021/acsbiomaterials.1c00225

Author

Kjeldsen, Rolf Bech ; Kristensen, Maja Nørgaard ; Gundlach, Carsten ; Thamdrup, Lasse Højlund Eklund ; Müllertz, Anette ; Rades, Thomas ; Nielsen, Line Hagner ; Zór, Kinga ; Boisen, Anja. / X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices. In: ACS Biomaterials Science and Engineering. 2021 ; Vol. 7, No. 6. pp. 2538–2547.

Bibtex

@article{86121a91b5724ed3a9c510205ef71657,
title = "X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices",
abstract = "Microscale devices are promising tools to overcome specific challenges within oral drug delivery. Despite the availability of advanced high-quality imaging techniques, visualization and tracking of microscale devices in the gastrointestinal (GI) tract is still a challenge. This work explores the possibilities of applying planar X-ray imaging and computed tomography (CT) scanning for visualization and tracking of microscale devices in the GI tract of rats. Microcontainers (MCs) are an example of microscale devices that have shown great potential as an oral drug delivery system. Barium sulfate (BaSO4) loaded into the cavity of the MCs increases their overall X-ray contrast, which allows them to be easily tracked. The BaSO4-loaded MCs are quantitatively tracked throughout the entire GI tract of rats by planar X-ray imaging and visualized in 3D by CT scanning. The majority of the BaSO4-loaded MCs are observed to retain in the stomach for 0.5-2 h, enter the cecum after 3-4 h, and leave the cecum and colon 8-10 h post-administration. The imaging approaches can be adopted and used with other types of microscale devices when investigating GI behavior in, for example, preclinical trials and potential clinical studies. ",
keywords = "barium sulfate, computed tomography scanning, gastrointestinal transit, microcontainers, planar X-ray imaging",
author = "Kjeldsen, {Rolf Bech} and Kristensen, {Maja N{\o}rgaard} and Carsten Gundlach and Thamdrup, {Lasse H{\o}jlund Eklund} and Anette M{\"u}llertz and Thomas Rades and Nielsen, {Line Hagner} and Kinga Z{\'o}r and Anja Boisen",
note = "Funding Information: The authors would like to acknowledge the Danish National Research Foundation (DNRF122) and Villum Fonden (Grant no. 9301) for Intelligent Drug Delivery and Sensing Using microcontainers and Nanomechanics (IDUN). Additionally, the animal facility at Department of Pharmacy at University of Copenhagen and the 3D Imaging Center at the Technical University of Denmark are acknowledged. Publisher Copyright: {\textcopyright} ",
year = "2021",
doi = "10.1021/acsbiomaterials.1c00225",
language = "English",
volume = "7",
pages = "2538–2547",
journal = "ACS Biomaterials Science and Engineering",
issn = "2373-9878",
publisher = "American Chemical Society",
number = "6",

}

RIS

TY - JOUR

T1 - X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices

AU - Kjeldsen, Rolf Bech

AU - Kristensen, Maja Nørgaard

AU - Gundlach, Carsten

AU - Thamdrup, Lasse Højlund Eklund

AU - Müllertz, Anette

AU - Rades, Thomas

AU - Nielsen, Line Hagner

AU - Zór, Kinga

AU - Boisen, Anja

N1 - Funding Information: The authors would like to acknowledge the Danish National Research Foundation (DNRF122) and Villum Fonden (Grant no. 9301) for Intelligent Drug Delivery and Sensing Using microcontainers and Nanomechanics (IDUN). Additionally, the animal facility at Department of Pharmacy at University of Copenhagen and the 3D Imaging Center at the Technical University of Denmark are acknowledged. Publisher Copyright: ©

PY - 2021

Y1 - 2021

N2 - Microscale devices are promising tools to overcome specific challenges within oral drug delivery. Despite the availability of advanced high-quality imaging techniques, visualization and tracking of microscale devices in the gastrointestinal (GI) tract is still a challenge. This work explores the possibilities of applying planar X-ray imaging and computed tomography (CT) scanning for visualization and tracking of microscale devices in the GI tract of rats. Microcontainers (MCs) are an example of microscale devices that have shown great potential as an oral drug delivery system. Barium sulfate (BaSO4) loaded into the cavity of the MCs increases their overall X-ray contrast, which allows them to be easily tracked. The BaSO4-loaded MCs are quantitatively tracked throughout the entire GI tract of rats by planar X-ray imaging and visualized in 3D by CT scanning. The majority of the BaSO4-loaded MCs are observed to retain in the stomach for 0.5-2 h, enter the cecum after 3-4 h, and leave the cecum and colon 8-10 h post-administration. The imaging approaches can be adopted and used with other types of microscale devices when investigating GI behavior in, for example, preclinical trials and potential clinical studies.

AB - Microscale devices are promising tools to overcome specific challenges within oral drug delivery. Despite the availability of advanced high-quality imaging techniques, visualization and tracking of microscale devices in the gastrointestinal (GI) tract is still a challenge. This work explores the possibilities of applying planar X-ray imaging and computed tomography (CT) scanning for visualization and tracking of microscale devices in the GI tract of rats. Microcontainers (MCs) are an example of microscale devices that have shown great potential as an oral drug delivery system. Barium sulfate (BaSO4) loaded into the cavity of the MCs increases their overall X-ray contrast, which allows them to be easily tracked. The BaSO4-loaded MCs are quantitatively tracked throughout the entire GI tract of rats by planar X-ray imaging and visualized in 3D by CT scanning. The majority of the BaSO4-loaded MCs are observed to retain in the stomach for 0.5-2 h, enter the cecum after 3-4 h, and leave the cecum and colon 8-10 h post-administration. The imaging approaches can be adopted and used with other types of microscale devices when investigating GI behavior in, for example, preclinical trials and potential clinical studies.

KW - barium sulfate

KW - computed tomography scanning

KW - gastrointestinal transit

KW - microcontainers

KW - planar X-ray imaging

U2 - 10.1021/acsbiomaterials.1c00225

DO - 10.1021/acsbiomaterials.1c00225

M3 - Journal article

C2 - 33856194

AN - SCOPUS:85105109281

VL - 7

SP - 2538

EP - 2547

JO - ACS Biomaterials Science and Engineering

JF - ACS Biomaterials Science and Engineering

SN - 2373-9878

IS - 6

ER -

ID: 273634719