Women with minor menstrual irregularities have increased risk of preeclampsia and low birthweight in spontaneous pregnancies
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Women with minor menstrual irregularities have increased risk of preeclampsia and low birthweight in spontaneous pregnancies. / Bonnesen, Barbara; Oddgeirsdóttir, Hanna L; Naver, Klara Vinsand; Jørgensen, Finn Stener; Nilas, Lisbeth.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 95, No. 1, 01.2016, p. 88-92.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Women with minor menstrual irregularities have increased risk of preeclampsia and low birthweight in spontaneous pregnancies
AU - Bonnesen, Barbara
AU - Oddgeirsdóttir, Hanna L
AU - Naver, Klara Vinsand
AU - Jørgensen, Finn Stener
AU - Nilas, Lisbeth
N1 - © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.
PY - 2016/1
Y1 - 2016/1
N2 - INTRODUCTION: Very few studies describe the obstetric and neonatal outcome of spontaneous pregnancies in women with irregular menstrual cycles. However, menstrual cycle irregularities are common and may be associated with increased risk, and women who develop pregnancy complications more frequently recollect irregular menstrual cycles before the time of conception in case-control studies.MATERIAL AND METHODS: This retrospective cohort study compares obstetric and neonatal outcomes in spontaneous singleton pregnancies in 3440 primiparous Danish women stratified according to menstrual cycle regularity. All pregnancies delivered after 22 weeks of gestation and had a nuchal translucency examination at Copenhagen University Hospital Hvidovre between 1 January 2009 and 31 December 2010. Menstrual cycle irregularity was defined as more than 7 days' deviation between self-reported and ultrasound examination-based gestational age. Outcome measures were gestational diabetes, hypertension, preeclampsia, preterm premature rupture of membranes, preterm birth, prolonged pregnancy, birthweight, umbilical artery pH <7.1, APGAR <7 after 5 min, admission to neonatal intensive care unit and stillbirth. Women with more than 7 days' deviation between self-reported and ultrasound examination-based gestational age were compared with women with a deviation of 7 days or less.RESULTS: Irregular menstrual cycle before conception increases the risk of preeclampsia (7.9% vs. 5.2%, p < 0.05) and low birthweight (6.0% vs. 3.6%, p < 0.05) in spontaneous pregnancies, but reduces the risk of prolonged pregnancy (1.4% vs. 4.7%, p < 0.001).CONCLUSION: Irregular menstrual cycle before conception is associated with increased risk of adverse obstetric and neonatal outcome.
AB - INTRODUCTION: Very few studies describe the obstetric and neonatal outcome of spontaneous pregnancies in women with irregular menstrual cycles. However, menstrual cycle irregularities are common and may be associated with increased risk, and women who develop pregnancy complications more frequently recollect irregular menstrual cycles before the time of conception in case-control studies.MATERIAL AND METHODS: This retrospective cohort study compares obstetric and neonatal outcomes in spontaneous singleton pregnancies in 3440 primiparous Danish women stratified according to menstrual cycle regularity. All pregnancies delivered after 22 weeks of gestation and had a nuchal translucency examination at Copenhagen University Hospital Hvidovre between 1 January 2009 and 31 December 2010. Menstrual cycle irregularity was defined as more than 7 days' deviation between self-reported and ultrasound examination-based gestational age. Outcome measures were gestational diabetes, hypertension, preeclampsia, preterm premature rupture of membranes, preterm birth, prolonged pregnancy, birthweight, umbilical artery pH <7.1, APGAR <7 after 5 min, admission to neonatal intensive care unit and stillbirth. Women with more than 7 days' deviation between self-reported and ultrasound examination-based gestational age were compared with women with a deviation of 7 days or less.RESULTS: Irregular menstrual cycle before conception increases the risk of preeclampsia (7.9% vs. 5.2%, p < 0.05) and low birthweight (6.0% vs. 3.6%, p < 0.05) in spontaneous pregnancies, but reduces the risk of prolonged pregnancy (1.4% vs. 4.7%, p < 0.001).CONCLUSION: Irregular menstrual cycle before conception is associated with increased risk of adverse obstetric and neonatal outcome.
KW - Adult
KW - Birth Weight
KW - Denmark
KW - Female
KW - Gestational Age
KW - Humans
KW - Infant, Low Birth Weight
KW - Infant, Newborn
KW - Menstruation Disturbances
KW - Pre-Eclampsia
KW - Pregnancy
KW - Pregnancy, Prolonged
KW - Retrospective Studies
KW - Risk Factors
KW - Ultrasonography, Prenatal
KW - Young Adult
U2 - 10.1111/aogs.12792
DO - 10.1111/aogs.12792
M3 - Journal article
C2 - 26453458
VL - 95
SP - 88
EP - 92
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 1
ER -
ID: 161698568