Voluntary ingestion of nut paste for administration of buprenorphine in rats and mice
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Voluntary ingestion of nut paste for administration of buprenorphine in rats and mice. / Abelson, Klas S P; Jacobsen, Kirsten R; Sundbom, Renée; Kalliokoski, Otto; Hau, Jann.
In: Laboratory Animals, Vol. 46, No. 4, 2012, p. 349-51.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Voluntary ingestion of nut paste for administration of buprenorphine in rats and mice
AU - Abelson, Klas S P
AU - Jacobsen, Kirsten R
AU - Sundbom, Renée
AU - Kalliokoski, Otto
AU - Hau, Jann
PY - 2012
Y1 - 2012
N2 - An adequate analgesic strategy is important to improve the postoperative recovery and welfare of laboratory rats and mice. It is desirable that the method for administering the drug is non-invasive and stress-free. We have previously validated a method for administering buprenorphine in a nut paste for voluntary ingestion. This method has many advantages over parenteral administration. To use the method in a successful way, however, it is important to prepare and administer the mix correctly. The present paper describes in detail how to implement the method, by means of habituation, presentation, adequate concentrations and amounts of buprenorphine/nut paste, and dosage of buprenorphine to rats and mice.
AB - An adequate analgesic strategy is important to improve the postoperative recovery and welfare of laboratory rats and mice. It is desirable that the method for administering the drug is non-invasive and stress-free. We have previously validated a method for administering buprenorphine in a nut paste for voluntary ingestion. This method has many advantages over parenteral administration. To use the method in a successful way, however, it is important to prepare and administer the mix correctly. The present paper describes in detail how to implement the method, by means of habituation, presentation, adequate concentrations and amounts of buprenorphine/nut paste, and dosage of buprenorphine to rats and mice.
U2 - 10.1258/la.2012.012028
DO - 10.1258/la.2012.012028
M3 - Journal article
C2 - 22969145
VL - 46
SP - 349
EP - 351
JO - Laboratory Animals
JF - Laboratory Animals
SN - 0023-6772
IS - 4
ER -
ID: 42014632