Vitamin D concentrations from neonatal dried blood spots and the risk of early-onset type 2 diabetes in the Danish D-tect case-cohort study

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Standard

Vitamin D concentrations from neonatal dried blood spots and the risk of early-onset type 2 diabetes in the Danish D-tect case-cohort study. / Keller, Amélie; Thorsteinsdottir, Fanney; Stougaard, Maria; Cardoso, Isabel; Frederiksen, Peder; Cohen, Arieh S; Vaag, Allan; Jacobsen, Ramune; Heitmann, Berit L.

In: Diabetologia, Vol. 64, 2021, p. 1572–1582.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Keller, A, Thorsteinsdottir, F, Stougaard, M, Cardoso, I, Frederiksen, P, Cohen, AS, Vaag, A, Jacobsen, R & Heitmann, BL 2021, 'Vitamin D concentrations from neonatal dried blood spots and the risk of early-onset type 2 diabetes in the Danish D-tect case-cohort study', Diabetologia, vol. 64, pp. 1572–1582. https://doi.org/10.1007/s00125-021-05450-2

APA

Keller, A., Thorsteinsdottir, F., Stougaard, M., Cardoso, I., Frederiksen, P., Cohen, A. S., Vaag, A., Jacobsen, R., & Heitmann, B. L. (2021). Vitamin D concentrations from neonatal dried blood spots and the risk of early-onset type 2 diabetes in the Danish D-tect case-cohort study. Diabetologia, 64, 1572–1582. https://doi.org/10.1007/s00125-021-05450-2

Vancouver

Keller A, Thorsteinsdottir F, Stougaard M, Cardoso I, Frederiksen P, Cohen AS et al. Vitamin D concentrations from neonatal dried blood spots and the risk of early-onset type 2 diabetes in the Danish D-tect case-cohort study. Diabetologia. 2021;64:1572–1582. https://doi.org/10.1007/s00125-021-05450-2

Author

Keller, Amélie ; Thorsteinsdottir, Fanney ; Stougaard, Maria ; Cardoso, Isabel ; Frederiksen, Peder ; Cohen, Arieh S ; Vaag, Allan ; Jacobsen, Ramune ; Heitmann, Berit L. / Vitamin D concentrations from neonatal dried blood spots and the risk of early-onset type 2 diabetes in the Danish D-tect case-cohort study. In: Diabetologia. 2021 ; Vol. 64. pp. 1572–1582.

Bibtex

@article{693334a9e5d548359ccd28c2ae420faa,
title = "Vitamin D concentrations from neonatal dried blood spots and the risk of early-onset type 2 diabetes in the Danish D-tect case-cohort study",
abstract = "AIMS/HYPOTHESIS: The aim of this study was to examine the influence of neonatal vitamin D concentration on the development of early-onset type 2 diabetes in a large population sample.METHODS: We conducted a case-cohort study utilising data from the Danish biobank and registers. Neonatal vitamin D was assessed measuring 25-hydroxyvitamin D3 [25(OH)D3] concentrations on the dried blood spot samples from the Biological Specimen Bank for Neonatal Screening. Cases of type 2 diabetes (n = 731) were retrieved from the Danish National Patient Register for all individuals born in Denmark between 1 May 1981 and 31 December 1992. The sub-cohort (n = 1765) was randomly selected from all children born in the same period. We used a weighted Cox proportional hazard model assessing the hazard of first type 2 diabetes diagnoses by quintiles of 25(OH)D3 and restricted cubic spline.RESULTS: The median 25(OH)D3 concentration (IQR) among cases was 21.3 nmol/l (13.3-34.1) and 23.9 nmol/l (13.7-35.7) in the sub-cohort. There was no indication of a potential lower risk of early-onset type 2 diabetes among individuals in the higher quintile of vitamin D concentration compared with the lowest (HRcrude 0.97 [95% CI 0.71, 1.33] p = 0.85; HRadjusted 1.29 [95% CI 0.92, 1.83] p = 0.14).CONCLUSIONS/INTERPRETATION: The results of this study do not support the hypothesis that higher neonatal vitamin D concentrations are associated with a lower risk of early-onset type 2 diabetes in adulthood.",
author = "Am{\'e}lie Keller and Fanney Thorsteinsdottir and Maria Stougaard and Isabel Cardoso and Peder Frederiksen and Cohen, {Arieh S} and Allan Vaag and Ramune Jacobsen and Heitmann, {Berit L}",
year = "2021",
doi = "10.1007/s00125-021-05450-2",
language = "English",
volume = "64",
pages = "1572–1582",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Vitamin D concentrations from neonatal dried blood spots and the risk of early-onset type 2 diabetes in the Danish D-tect case-cohort study

AU - Keller, Amélie

AU - Thorsteinsdottir, Fanney

AU - Stougaard, Maria

AU - Cardoso, Isabel

AU - Frederiksen, Peder

AU - Cohen, Arieh S

AU - Vaag, Allan

AU - Jacobsen, Ramune

AU - Heitmann, Berit L

PY - 2021

Y1 - 2021

N2 - AIMS/HYPOTHESIS: The aim of this study was to examine the influence of neonatal vitamin D concentration on the development of early-onset type 2 diabetes in a large population sample.METHODS: We conducted a case-cohort study utilising data from the Danish biobank and registers. Neonatal vitamin D was assessed measuring 25-hydroxyvitamin D3 [25(OH)D3] concentrations on the dried blood spot samples from the Biological Specimen Bank for Neonatal Screening. Cases of type 2 diabetes (n = 731) were retrieved from the Danish National Patient Register for all individuals born in Denmark between 1 May 1981 and 31 December 1992. The sub-cohort (n = 1765) was randomly selected from all children born in the same period. We used a weighted Cox proportional hazard model assessing the hazard of first type 2 diabetes diagnoses by quintiles of 25(OH)D3 and restricted cubic spline.RESULTS: The median 25(OH)D3 concentration (IQR) among cases was 21.3 nmol/l (13.3-34.1) and 23.9 nmol/l (13.7-35.7) in the sub-cohort. There was no indication of a potential lower risk of early-onset type 2 diabetes among individuals in the higher quintile of vitamin D concentration compared with the lowest (HRcrude 0.97 [95% CI 0.71, 1.33] p = 0.85; HRadjusted 1.29 [95% CI 0.92, 1.83] p = 0.14).CONCLUSIONS/INTERPRETATION: The results of this study do not support the hypothesis that higher neonatal vitamin D concentrations are associated with a lower risk of early-onset type 2 diabetes in adulthood.

AB - AIMS/HYPOTHESIS: The aim of this study was to examine the influence of neonatal vitamin D concentration on the development of early-onset type 2 diabetes in a large population sample.METHODS: We conducted a case-cohort study utilising data from the Danish biobank and registers. Neonatal vitamin D was assessed measuring 25-hydroxyvitamin D3 [25(OH)D3] concentrations on the dried blood spot samples from the Biological Specimen Bank for Neonatal Screening. Cases of type 2 diabetes (n = 731) were retrieved from the Danish National Patient Register for all individuals born in Denmark between 1 May 1981 and 31 December 1992. The sub-cohort (n = 1765) was randomly selected from all children born in the same period. We used a weighted Cox proportional hazard model assessing the hazard of first type 2 diabetes diagnoses by quintiles of 25(OH)D3 and restricted cubic spline.RESULTS: The median 25(OH)D3 concentration (IQR) among cases was 21.3 nmol/l (13.3-34.1) and 23.9 nmol/l (13.7-35.7) in the sub-cohort. There was no indication of a potential lower risk of early-onset type 2 diabetes among individuals in the higher quintile of vitamin D concentration compared with the lowest (HRcrude 0.97 [95% CI 0.71, 1.33] p = 0.85; HRadjusted 1.29 [95% CI 0.92, 1.83] p = 0.14).CONCLUSIONS/INTERPRETATION: The results of this study do not support the hypothesis that higher neonatal vitamin D concentrations are associated with a lower risk of early-onset type 2 diabetes in adulthood.

U2 - 10.1007/s00125-021-05450-2

DO - 10.1007/s00125-021-05450-2

M3 - Journal article

C2 - 34028586

VL - 64

SP - 1572

EP - 1582

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

ER -

ID: 269607290