Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure. / Hinterseer, Martin; Beckmann, Britt-Maria; Thomsen, Morten Bækgaard; Pfeufer, Arne; Ulbrich, Michael; Sinner, Moritz F; Perz, Siegfried; Wichmann, H-Erich; Lengyel, Csaba; Schimpf, Rainer; Maier, Sebastian K G; Varró, András; Vos, Marc A; Steinbeck, Gerhard; Kääb, Stefan.

In: Journal of the American College of Cardiology, Vol. 106, No. 2, 15.07.2010, p. 216-20.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hinterseer, M, Beckmann, B-M, Thomsen, MB, Pfeufer, A, Ulbrich, M, Sinner, MF, Perz, S, Wichmann, H-E, Lengyel, C, Schimpf, R, Maier, SKG, Varró, A, Vos, MA, Steinbeck, G & Kääb, S 2010, 'Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure', Journal of the American College of Cardiology, vol. 106, no. 2, pp. 216-20. https://doi.org/10.1016/j.amjcard.2010.02.033

APA

Hinterseer, M., Beckmann, B-M., Thomsen, M. B., Pfeufer, A., Ulbrich, M., Sinner, M. F., Perz, S., Wichmann, H-E., Lengyel, C., Schimpf, R., Maier, S. K. G., Varró, A., Vos, M. A., Steinbeck, G., & Kääb, S. (2010). Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure. Journal of the American College of Cardiology, 106(2), 216-20. https://doi.org/10.1016/j.amjcard.2010.02.033

Vancouver

Hinterseer M, Beckmann B-M, Thomsen MB, Pfeufer A, Ulbrich M, Sinner MF et al. Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure. Journal of the American College of Cardiology. 2010 Jul 15;106(2):216-20. https://doi.org/10.1016/j.amjcard.2010.02.033

Author

Hinterseer, Martin ; Beckmann, Britt-Maria ; Thomsen, Morten Bækgaard ; Pfeufer, Arne ; Ulbrich, Michael ; Sinner, Moritz F ; Perz, Siegfried ; Wichmann, H-Erich ; Lengyel, Csaba ; Schimpf, Rainer ; Maier, Sebastian K G ; Varró, András ; Vos, Marc A ; Steinbeck, Gerhard ; Kääb, Stefan. / Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure. In: Journal of the American College of Cardiology. 2010 ; Vol. 106, No. 2. pp. 216-20.

Bibtex

@article{c358d70b16ae48bbb676ccaa4bcc80d4,

title = "Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure",

abstract = "The high incidence of sudden cardiac death in heart failure (HF) reflects electrophysiologic changes in response to myocardial failure. We previously showed that short-term variability of QT intervals (STV(QT)) identifies latent repolarization disorders in patients with drug-induced or congenital long QT syndrome. This study sought to determine (1) if STV(QT) is increased in patients with dilated cardiomyopathy (DC) and moderate congestive HF and (2) if increased STV(QT) is associated with ventricular arrhythmia in patients with HF. Sixty patients (53 +/- 12 years of age, 14 women) with DC and moderate HF (New York Heart Association classes II to III) were compared to matched controls. Twenty patients had implantable cardiac defibrillators secondary to a history of ventricular tachycardia (VT). Two cardiologists blinded to diagnosis manually measured QT intervals. Beat-to-beat variability of repolarization was determined from Poincar{\'e} plots of 30 consecutive QT intervals as was STV(QT). QTc intervals were comparable in patients and controls (419 +/- 36 vs 415 +/- 32 ms, respectively, p >0.05), whereas STV(QT) was significantly higher in patients with HF (7.8 +/- 3 vs 4.1 +/- 2 ms, respectively, p ",

keywords = "Adult, Aged, Arrhythmias, Cardiac, Cardiac Electrophysiology, Electrocardiography, Female, Heart Failure, Humans, Male, Middle Aged, Predictive Value of Tests, Severity of Illness Index",

author = "Martin Hinterseer and Britt-Maria Beckmann and Thomsen, {Morten B{\ae}kgaard} and Arne Pfeufer and Michael Ulbrich and Sinner, {Moritz F} and Siegfried Perz and H-Erich Wichmann and Csaba Lengyel and Rainer Schimpf and Maier, {Sebastian K G} and Andr{\'a}s Varr{\'o} and Vos, {Marc A} and Gerhard Steinbeck and Stefan K{\"a}{\"a}b",

year = "2010",

month = jul,

day = "15",

doi = "10.1016/j.amjcard.2010.02.033",

language = "English",

volume = "106",

pages = "216--20",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier",

number = "2",

}

RIS

TY - JOUR

T1 - Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure

AU - Hinterseer, Martin

AU - Beckmann, Britt-Maria

AU - Thomsen, Morten Bækgaard

AU - Pfeufer, Arne

AU - Ulbrich, Michael

AU - Sinner, Moritz F

AU - Perz, Siegfried

AU - Wichmann, H-Erich

AU - Lengyel, Csaba

AU - Schimpf, Rainer

AU - Maier, Sebastian K G

AU - Varró, András

AU - Vos, Marc A

AU - Steinbeck, Gerhard

AU - Kääb, Stefan

PY - 2010/7/15

Y1 - 2010/7/15

N2 - The high incidence of sudden cardiac death in heart failure (HF) reflects electrophysiologic changes in response to myocardial failure. We previously showed that short-term variability of QT intervals (STV(QT)) identifies latent repolarization disorders in patients with drug-induced or congenital long QT syndrome. This study sought to determine (1) if STV(QT) is increased in patients with dilated cardiomyopathy (DC) and moderate congestive HF and (2) if increased STV(QT) is associated with ventricular arrhythmia in patients with HF. Sixty patients (53 +/- 12 years of age, 14 women) with DC and moderate HF (New York Heart Association classes II to III) were compared to matched controls. Twenty patients had implantable cardiac defibrillators secondary to a history of ventricular tachycardia (VT). Two cardiologists blinded to diagnosis manually measured QT intervals. Beat-to-beat variability of repolarization was determined from Poincaré plots of 30 consecutive QT intervals as was STV(QT). QTc intervals were comparable in patients and controls (419 +/- 36 vs 415 +/- 32 ms, respectively, p >0.05), whereas STV(QT) was significantly higher in patients with HF (7.8 +/- 3 vs 4.1 +/- 2 ms, respectively, p

AB - The high incidence of sudden cardiac death in heart failure (HF) reflects electrophysiologic changes in response to myocardial failure. We previously showed that short-term variability of QT intervals (STV(QT)) identifies latent repolarization disorders in patients with drug-induced or congenital long QT syndrome. This study sought to determine (1) if STV(QT) is increased in patients with dilated cardiomyopathy (DC) and moderate congestive HF and (2) if increased STV(QT) is associated with ventricular arrhythmia in patients with HF. Sixty patients (53 +/- 12 years of age, 14 women) with DC and moderate HF (New York Heart Association classes II to III) were compared to matched controls. Twenty patients had implantable cardiac defibrillators secondary to a history of ventricular tachycardia (VT). Two cardiologists blinded to diagnosis manually measured QT intervals. Beat-to-beat variability of repolarization was determined from Poincaré plots of 30 consecutive QT intervals as was STV(QT). QTc intervals were comparable in patients and controls (419 +/- 36 vs 415 +/- 32 ms, respectively, p >0.05), whereas STV(QT) was significantly higher in patients with HF (7.8 +/- 3 vs 4.1 +/- 2 ms, respectively, p

KW - Adult

KW - Aged

KW - Arrhythmias, Cardiac

KW - Cardiac Electrophysiology

KW - Electrocardiography

KW - Female

KW - Heart Failure

KW - Humans

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Severity of Illness Index

U2 - 10.1016/j.amjcard.2010.02.033

DO - 10.1016/j.amjcard.2010.02.033

M3 - Journal article

C2 - 20599006

VL - 106

SP - 216

EP - 220

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 2

ER -

ID: 33744466