Ultra Sensitive Micro String Resonators for Solid State Thermomechanical Analysis of Small and Large Molecules

Research output: Contribution to journalJournal articlepeer-review

Standard

Ultra Sensitive Micro String Resonators for Solid State Thermomechanical Analysis of Small and Large Molecules. / Karl, Maximilian; Larsen, Peter Emil; Rangacharya, Varadarajan; Hwu, En Te; Rantanen, Jukka; Boisen, Anja; Rades, Thomas.

In: Journal of the American Chemical Society, Vol. 140, No. 50, 19.12.2018, p. 17522-17531.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Karl, M, Larsen, PE, Rangacharya, V, Hwu, ET, Rantanen, J, Boisen, A & Rades, T 2018, 'Ultra Sensitive Micro String Resonators for Solid State Thermomechanical Analysis of Small and Large Molecules', Journal of the American Chemical Society, vol. 140, no. 50, pp. 17522-17531. https://doi.org/10.1021/jacs.8b09034

APA

Karl, M., Larsen, P. E., Rangacharya, V., Hwu, E. T., Rantanen, J., Boisen, A., & Rades, T. (2018). Ultra Sensitive Micro String Resonators for Solid State Thermomechanical Analysis of Small and Large Molecules. Journal of the American Chemical Society, 140(50), 17522-17531. https://doi.org/10.1021/jacs.8b09034

Vancouver

Karl M, Larsen PE, Rangacharya V, Hwu ET, Rantanen J, Boisen A et al. Ultra Sensitive Micro String Resonators for Solid State Thermomechanical Analysis of Small and Large Molecules. Journal of the American Chemical Society. 2018 Dec 19;140(50):17522-17531. https://doi.org/10.1021/jacs.8b09034

Author

Karl, Maximilian ; Larsen, Peter Emil ; Rangacharya, Varadarajan ; Hwu, En Te ; Rantanen, Jukka ; Boisen, Anja ; Rades, Thomas. / Ultra Sensitive Micro String Resonators for Solid State Thermomechanical Analysis of Small and Large Molecules. In: Journal of the American Chemical Society. 2018 ; Vol. 140, No. 50. pp. 17522-17531.

Bibtex

@article{bc0c4670077945a7aa74d98a649c1694,
title = "Ultra Sensitive Micro String Resonators for Solid State Thermomechanical Analysis of Small and Large Molecules",
abstract = "Thermal analysis plays an important role in both industrial and fundamental research and is widely used to study thermal characteristics of a variety of materials. However, despite considerable effort using different techniques, research struggles to resolve the physico-chemical nature of many thermal transitions such as amorphous relaxations or structural changes in proteins. To overcome the limitations in sensitivity of conventional techniques and to gain new insight into the thermal and mechanical properties of small and large molecule samples, we have developed an instrumental analysis technique using resonating low stress silicon nitride microstrings. With a simple sample deposition method and post process data analysis, we are able to perform rapid thermal analysis of direct instrumental triplicate samples with only pico- to nanograms of material. Utilizing this method, we present the first measurement of amorphous alpha and beta relaxation, as well as liquid crystalline transitions and decomposition of small molecule samples deposited onto a micro string resonator. Furthermore, sensitive measurements of the glass transition of polymers and yet unresolved thermal responses of proteins below their apparent denaturation temperature, which seem to include the true solid state glass transition of pure protein, are reported. Where applicable, thermal events detected with the setup were in good agreement with conventional techniques such as differential scanning calorimetry and dynamic mechanical analysis. The sensitive detection of even subtle thermal transitions highlights further possibilities and applications of resonating microstrings in instrumental physico-chemical analysis.",
author = "Maximilian Karl and Larsen, {Peter Emil} and Varadarajan Rangacharya and Hwu, {En Te} and Jukka Rantanen and Anja Boisen and Thomas Rades",
year = "2018",
month = dec,
day = "19",
doi = "10.1021/jacs.8b09034",
language = "English",
volume = "140",
pages = "17522--17531",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "ACS Publications",
number = "50",

}

RIS

TY - JOUR

T1 - Ultra Sensitive Micro String Resonators for Solid State Thermomechanical Analysis of Small and Large Molecules

AU - Karl, Maximilian

AU - Larsen, Peter Emil

AU - Rangacharya, Varadarajan

AU - Hwu, En Te

AU - Rantanen, Jukka

AU - Boisen, Anja

AU - Rades, Thomas

PY - 2018/12/19

Y1 - 2018/12/19

N2 - Thermal analysis plays an important role in both industrial and fundamental research and is widely used to study thermal characteristics of a variety of materials. However, despite considerable effort using different techniques, research struggles to resolve the physico-chemical nature of many thermal transitions such as amorphous relaxations or structural changes in proteins. To overcome the limitations in sensitivity of conventional techniques and to gain new insight into the thermal and mechanical properties of small and large molecule samples, we have developed an instrumental analysis technique using resonating low stress silicon nitride microstrings. With a simple sample deposition method and post process data analysis, we are able to perform rapid thermal analysis of direct instrumental triplicate samples with only pico- to nanograms of material. Utilizing this method, we present the first measurement of amorphous alpha and beta relaxation, as well as liquid crystalline transitions and decomposition of small molecule samples deposited onto a micro string resonator. Furthermore, sensitive measurements of the glass transition of polymers and yet unresolved thermal responses of proteins below their apparent denaturation temperature, which seem to include the true solid state glass transition of pure protein, are reported. Where applicable, thermal events detected with the setup were in good agreement with conventional techniques such as differential scanning calorimetry and dynamic mechanical analysis. The sensitive detection of even subtle thermal transitions highlights further possibilities and applications of resonating microstrings in instrumental physico-chemical analysis.

AB - Thermal analysis plays an important role in both industrial and fundamental research and is widely used to study thermal characteristics of a variety of materials. However, despite considerable effort using different techniques, research struggles to resolve the physico-chemical nature of many thermal transitions such as amorphous relaxations or structural changes in proteins. To overcome the limitations in sensitivity of conventional techniques and to gain new insight into the thermal and mechanical properties of small and large molecule samples, we have developed an instrumental analysis technique using resonating low stress silicon nitride microstrings. With a simple sample deposition method and post process data analysis, we are able to perform rapid thermal analysis of direct instrumental triplicate samples with only pico- to nanograms of material. Utilizing this method, we present the first measurement of amorphous alpha and beta relaxation, as well as liquid crystalline transitions and decomposition of small molecule samples deposited onto a micro string resonator. Furthermore, sensitive measurements of the glass transition of polymers and yet unresolved thermal responses of proteins below their apparent denaturation temperature, which seem to include the true solid state glass transition of pure protein, are reported. Where applicable, thermal events detected with the setup were in good agreement with conventional techniques such as differential scanning calorimetry and dynamic mechanical analysis. The sensitive detection of even subtle thermal transitions highlights further possibilities and applications of resonating microstrings in instrumental physico-chemical analysis.

U2 - 10.1021/jacs.8b09034

DO - 10.1021/jacs.8b09034

M3 - Journal article

C2 - 30468581

VL - 140

SP - 17522

EP - 17531

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 50

ER -

ID: 209710741