Type 1 diabetes is associated with T-wave morphology changes: The Thousand & 1 Study
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Type 1 diabetes is associated with T-wave morphology changes : The Thousand & 1 Study. / Isaksen, Jonas L.; Graff, Claus; Ellervik, Christina; Jensen, Jan Skov; Andersen, Henrik Ullits; Rossing, Peter; Kanters, Jørgen K.; Jensen, Magnus Thorsten.
In: Journal of Electrocardiology, Vol. 51, No. 6, 01.11.2018, p. S72-S77.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Type 1 diabetes is associated with T-wave morphology changes
T2 - The Thousand & 1 Study
AU - Isaksen, Jonas L.
AU - Graff, Claus
AU - Ellervik, Christina
AU - Jensen, Jan Skov
AU - Andersen, Henrik Ullits
AU - Rossing, Peter
AU - Kanters, Jørgen K.
AU - Jensen, Magnus Thorsten
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Background: Repolarization is impaired in patients with type 1 diabetes mellitus (T1DM), and repolarization disturbances are associated with an increased mortality. To study cardiac repolarization, we assessed T-wave morphology in patients with T1DM without known heart disease. Methods: 855 T1DM patients without known heart disease were matched 1:2 with 1710 people from a background population. Rate-corrected T-wave morphology markers were obtained. Patients were stratified by albuminuria. Results are mean ± standard deviation. Results: T-waves were flatter (0.398 ± 0.059 vs. 0.382 ± 0.062, p < 0.001) and more asymmetric (0.082 ± 0.068 vs. 0.071 ± 0.084, p = 0.001) in T1DM. Patients with albuminuria had an increased heart rate (normoalbuminuria: 71 ± 13 bpm, microalbuminuria: 75 ± 12 bpm, p < 0.001, macroalbuminuria: 78 ± 12 bpm, p < 0.001) and more asymmetric T-waves (normoalbuminuria: 0.079 ± 0.060, microalbuminuria: 0.094 ± 0.085, p < 0.01, macroalbuminuria: 0.101 ± 0.080, p < 0.01), but the QTc interval remained unchanged. Conclusions: T1DM is associated with changes in T-wave morphology. T-wave asymmetry but not QTc interval is associated with albuminuria in T1DM and may be used for stratification.
AB - Background: Repolarization is impaired in patients with type 1 diabetes mellitus (T1DM), and repolarization disturbances are associated with an increased mortality. To study cardiac repolarization, we assessed T-wave morphology in patients with T1DM without known heart disease. Methods: 855 T1DM patients without known heart disease were matched 1:2 with 1710 people from a background population. Rate-corrected T-wave morphology markers were obtained. Patients were stratified by albuminuria. Results are mean ± standard deviation. Results: T-waves were flatter (0.398 ± 0.059 vs. 0.382 ± 0.062, p < 0.001) and more asymmetric (0.082 ± 0.068 vs. 0.071 ± 0.084, p = 0.001) in T1DM. Patients with albuminuria had an increased heart rate (normoalbuminuria: 71 ± 13 bpm, microalbuminuria: 75 ± 12 bpm, p < 0.001, macroalbuminuria: 78 ± 12 bpm, p < 0.001) and more asymmetric T-waves (normoalbuminuria: 0.079 ± 0.060, microalbuminuria: 0.094 ± 0.085, p < 0.01, macroalbuminuria: 0.101 ± 0.080, p < 0.01), but the QTc interval remained unchanged. Conclusions: T1DM is associated with changes in T-wave morphology. T-wave asymmetry but not QTc interval is associated with albuminuria in T1DM and may be used for stratification.
UR - http://www.scopus.com/inward/record.url?scp=85049652745&partnerID=8YFLogxK
U2 - 10.1016/j.jelectrocard.2018.05.015
DO - 10.1016/j.jelectrocard.2018.05.015
M3 - Journal article
C2 - 30007776
VL - 51
SP - S72-S77
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
SN - 0022-0736
IS - 6
ER -
ID: 198564122