Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease

Research output: Contribution to journal › Journal article › Research › peer-review

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Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease. / Nielsen, Ole Haagen; Ainsworth, Mark Andrew.

In: New England Journal of Medicine, Vol. 369, 2013, p. 754-762.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, OH & Ainsworth, MA 2013, 'Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease', New England Journal of Medicine, vol. 369, pp. 754-762. https://doi.org/10.1056/NEJMct1209614

APA

Nielsen, O. H., & Ainsworth, M. A. (2013). Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease. New England Journal of Medicine, 369, 754-762. https://doi.org/10.1056/NEJMct1209614

Vancouver

Nielsen OH, Ainsworth MA. Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease. New England Journal of Medicine. 2013;369:754-762. https://doi.org/10.1056/NEJMct1209614

Author

Nielsen, Ole Haagen ; Ainsworth, Mark Andrew. / Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease. In: New England Journal of Medicine. 2013 ; Vol. 369. pp. 754-762.

Bibtex

@article{d2ce6ba0fd1f4d5fb3851924e849875a,
title = "Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease",
abstract = "A 35-year-old man presents with an exacerbation of Crohn's ileocolitis. He received a diagnosis of Crohn's disease 8 years ago and has been treated on three previous occasions with prednisone. Because of a recurrent need for glucocorticoids, treatment with azathioprine (150 mg per day) was started 1 year ago. He now reports abdominal pain in the right lower quadrant, which developed 1 week ago, with an increase in stool frequency to eight to nine stools per day. Laboratory tests show a hemoglobin concentration of 10.7 g per deciliter and a C-reactive protein level of 21 mg per liter. Magnetic resonance enterography shows inflammation localized to the distal ileum and colon. The patient is referred to a gastroenterologist. An ileocolonoscopy reveals patchy erythema and ulcerations near the hepatic flexure as well as similar lesions in the terminal ileum. Biopsy specimens obtained during colonoscopy show acute and chronic granulomatous inflammation, and the gastroenterologist recommends treatment with a tumor necrosis factor (TNF) inhibitor.",
author = "Nielsen, {Ole Haagen} and Ainsworth, {Mark Andrew}",
year = "2013",
doi = "10.1056/NEJMct1209614",
language = "English",
volume = "369",
pages = "754--762",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachusetts Medical Society",

}

RIS

TY - JOUR

T1 - Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease

AU - Nielsen, Ole Haagen

AU - Ainsworth, Mark Andrew

PY - 2013

Y1 - 2013

N2 - A 35-year-old man presents with an exacerbation of Crohn's ileocolitis. He received a diagnosis of Crohn's disease 8 years ago and has been treated on three previous occasions with prednisone. Because of a recurrent need for glucocorticoids, treatment with azathioprine (150 mg per day) was started 1 year ago. He now reports abdominal pain in the right lower quadrant, which developed 1 week ago, with an increase in stool frequency to eight to nine stools per day. Laboratory tests show a hemoglobin concentration of 10.7 g per deciliter and a C-reactive protein level of 21 mg per liter. Magnetic resonance enterography shows inflammation localized to the distal ileum and colon. The patient is referred to a gastroenterologist. An ileocolonoscopy reveals patchy erythema and ulcerations near the hepatic flexure as well as similar lesions in the terminal ileum. Biopsy specimens obtained during colonoscopy show acute and chronic granulomatous inflammation, and the gastroenterologist recommends treatment with a tumor necrosis factor (TNF) inhibitor.

AB - A 35-year-old man presents with an exacerbation of Crohn's ileocolitis. He received a diagnosis of Crohn's disease 8 years ago and has been treated on three previous occasions with prednisone. Because of a recurrent need for glucocorticoids, treatment with azathioprine (150 mg per day) was started 1 year ago. He now reports abdominal pain in the right lower quadrant, which developed 1 week ago, with an increase in stool frequency to eight to nine stools per day. Laboratory tests show a hemoglobin concentration of 10.7 g per deciliter and a C-reactive protein level of 21 mg per liter. Magnetic resonance enterography shows inflammation localized to the distal ileum and colon. The patient is referred to a gastroenterologist. An ileocolonoscopy reveals patchy erythema and ulcerations near the hepatic flexure as well as similar lesions in the terminal ileum. Biopsy specimens obtained during colonoscopy show acute and chronic granulomatous inflammation, and the gastroenterologist recommends treatment with a tumor necrosis factor (TNF) inhibitor.

U2 - 10.1056/NEJMct1209614

DO - 10.1056/NEJMct1209614

M3 - Journal article

C2 - 23964937

VL - 369

SP - 754

EP - 762

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

ER -

ID: 98160285