Triangulation of the monophasic action potential causes flattening of the electrocardiographic T-wave
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
It has been proposed that triangulation on the cardiac action potential manifests as a broadened, more flat and notched T-wave on the ECG but to what extent such morphology characteristics are indicative of triangulation is more unclear. In this paper, we have analyzed the morphological changes of the action potential under the effect of the IKr blocker sertindole and associated these changes to concurrent changes in the morphology of electrocardiographic T-waves in dogs. We show that, under the effect of sertindole, the peak changes in the morphology of action potentials occur at time points similar to those observed for the peak changes in T-wave morphology on the ECG. We further show that the association between action potential shape and ECG shape is dose-dependent and most prominent at the time corresponding to phase 3 of the action potential.
|Title of host publication||Computing in Cardiology|
|Number of pages||4|
|Publication date||1 Jan 2012|
|Publication status||Published - 1 Jan 2012|