Trends in antidepressant use among children and adolescents: a Scandinavian drug utilization study
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Trends in antidepressant use among children and adolescents : a Scandinavian drug utilization study. / Wesselhoeft, R; Jensen, P B; Talati, A; Reutfors, J; Furu, K; Strandberg-Larsen, K; Damkier, P; Pottegård, A; Bliddal, M.
In: Acta Psychiatrica Scandinavica, Vol. 141, No. 1, 2020, p. 34-42.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Trends in antidepressant use among children and adolescents
T2 - a Scandinavian drug utilization study
AU - Wesselhoeft, R
AU - Jensen, P B
AU - Talati, A
AU - Reutfors, J
AU - Furu, K
AU - Strandberg-Larsen, K
AU - Damkier, P
AU - Pottegård, A
AU - Bliddal, M
N1 - © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2020
Y1 - 2020
N2 - OBJECTIVE: To compare antidepressant utilization in individuals aged 5-19 years from the Scandinavian countries.METHODS: A population-based drug utilization study using publicly available data of antidepressant use from Denmark, Norway, and Sweden.RESULTS: In the study period from 2007 to 2017, the proportion of antidepressant users increased markedly in Sweden (9.3-18.0/1000) compared to Norway (5.1-7.6/1000) and Denmark (9.3-7.5/1000). In 2017, the cumulated defined daily doses (DDD) of selective serotonin reuptake inhibitors were 5611/1000 inhabitants in Sweden, 2709/1000 in Denmark, and 1848/1000 in Norway. The use of 'other antidepressants' (ATC code N06AX) also increased in Sweden with a higher DDD in 2017 (497/1000) compared to Denmark (225/1000) and Norway (170/1000). The use of tricyclic antidepressants was generally low in 2017 with DDDs ranging between 30-42 per 1000. The proportion of antidepressant users was highest among 15- to 19-year-old individuals. Girls were more likely to receive treatment than boys, and the treated female/male ratios per 1000 were similar in Sweden (2.39), Denmark (2.44), and Norway (2.63).CONCLUSION: Even in highly comparable healthcare systems like the Scandinavian countries', variation in antidepressant use is considerable. Swedish children and adolescents have a markedly higher and still increasing use of antidepressants compared to Danish and Norwegian peers.
AB - OBJECTIVE: To compare antidepressant utilization in individuals aged 5-19 years from the Scandinavian countries.METHODS: A population-based drug utilization study using publicly available data of antidepressant use from Denmark, Norway, and Sweden.RESULTS: In the study period from 2007 to 2017, the proportion of antidepressant users increased markedly in Sweden (9.3-18.0/1000) compared to Norway (5.1-7.6/1000) and Denmark (9.3-7.5/1000). In 2017, the cumulated defined daily doses (DDD) of selective serotonin reuptake inhibitors were 5611/1000 inhabitants in Sweden, 2709/1000 in Denmark, and 1848/1000 in Norway. The use of 'other antidepressants' (ATC code N06AX) also increased in Sweden with a higher DDD in 2017 (497/1000) compared to Denmark (225/1000) and Norway (170/1000). The use of tricyclic antidepressants was generally low in 2017 with DDDs ranging between 30-42 per 1000. The proportion of antidepressant users was highest among 15- to 19-year-old individuals. Girls were more likely to receive treatment than boys, and the treated female/male ratios per 1000 were similar in Sweden (2.39), Denmark (2.44), and Norway (2.63).CONCLUSION: Even in highly comparable healthcare systems like the Scandinavian countries', variation in antidepressant use is considerable. Swedish children and adolescents have a markedly higher and still increasing use of antidepressants compared to Danish and Norwegian peers.
KW - Adolescent
KW - Age Factors
KW - Antidepressive Agents/therapeutic use
KW - Antidepressive Agents, Tricyclic/therapeutic use
KW - Child
KW - Child, Preschool
KW - Denmark
KW - Drug Labeling/statistics & numerical data
KW - Drug Utilization/trends
KW - Female
KW - Humans
KW - Male
KW - Norway
KW - Scandinavian and Nordic Countries
KW - Serotonin Uptake Inhibitors/therapeutic use
KW - Sex Factors
KW - Sweden
KW - Young Adult
U2 - 10.1111/acps.13116
DO - 10.1111/acps.13116
M3 - Journal article
C2 - 31618447
VL - 141
SP - 34
EP - 42
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 1
ER -
ID: 259673102