Trefoil factor peptides in serum and sputum from subjects with asthma and COPD

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Trefoil factor peptides in serum and sputum from subjects with asthma and COPD. / Viby, Niels-Erik; Pedersen, Lars; Lund, Thomas Kromann; Kissow, Hannelouise; Backer, Vibeke; Nexø, Ebba; Thim, Lars; Poulsen, Steen Seier.

In: Clinical Respiratory Journal, Vol. 9, No. 3, 07.2015, p. 322-329.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Viby, N-E, Pedersen, L, Lund, TK, Kissow, H, Backer, V, Nexø, E, Thim, L & Poulsen, SS 2015, 'Trefoil factor peptides in serum and sputum from subjects with asthma and COPD', Clinical Respiratory Journal, vol. 9, no. 3, pp. 322-329. https://doi.org/10.1111/crj.12146

APA

Viby, N-E., Pedersen, L., Lund, T. K., Kissow, H., Backer, V., Nexø, E., ... Poulsen, S. S. (2015). Trefoil factor peptides in serum and sputum from subjects with asthma and COPD. Clinical Respiratory Journal, 9(3), 322-329. https://doi.org/10.1111/crj.12146

Vancouver

Viby N-E, Pedersen L, Lund TK, Kissow H, Backer V, Nexø E et al. Trefoil factor peptides in serum and sputum from subjects with asthma and COPD. Clinical Respiratory Journal. 2015 Jul;9(3):322-329. https://doi.org/10.1111/crj.12146

Author

Viby, Niels-Erik ; Pedersen, Lars ; Lund, Thomas Kromann ; Kissow, Hannelouise ; Backer, Vibeke ; Nexø, Ebba ; Thim, Lars ; Poulsen, Steen Seier. / Trefoil factor peptides in serum and sputum from subjects with asthma and COPD. In: Clinical Respiratory Journal. 2015 ; Vol. 9, No. 3. pp. 322-329.

Bibtex

@article{0eb910fd86ca4942aade7b108f0df5dd,
title = "Trefoil factor peptides in serum and sputum from subjects with asthma and COPD",
abstract = "Objective: Trefoil factor peptides (TFF) are secreted onto mucosal surfaces together with mucins and occur in high concentrations in pulmonary secretions from patients with chronic obstructive pulmonary disease (COPD). In the present study, we aimed to explore the concentrations of the peptides in serum and sputum in patients with COPD.Materials and Methods: Thirty-five individuals were included in the study, including 11 healthy individuals, 13 indivials with asthma and 11 individuals with COPD. TFF1, TFF2 and TFF3 were measured by enzyme-linked immunosorbent assay (ELISA) in sputum induced by hypertonic saline inhalation and in serum. Total protein content in sputum was also determined.Results: In the sputum samples from COPD patients, we observed an eightfold higher concentration of TFF1 and a fivefold higher concentration of TFF3 compared with controls. In the serum samples from COPD patients, we observed three-, three- and twofold higher concentrations of TFF1, TFF2 and TFF3 respectively compared with controls.Conclusions: There is increased secretion of TFF peptides in the lungs of patients with COPD, as well as significant increases in serum levels. This suggests a role for TFF peptides in the pathogenesis of pulmonary diseases with mucus hypersecretion.",
author = "Niels-Erik Viby and Lars Pedersen and Lund, {Thomas Kromann} and Hannelouise Kissow and Vibeke Backer and Ebba Nex{\o} and Lars Thim and Poulsen, {Steen Seier}",
note = "This article is protected by copyright. All rights reserved.",
year = "2015",
month = "7",
doi = "10.1111/crj.12146",
language = "English",
volume = "9",
pages = "322--329",
journal = "Clinical Respiratory Journal",
issn = "1752-6981",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Trefoil factor peptides in serum and sputum from subjects with asthma and COPD

AU - Viby, Niels-Erik

AU - Pedersen, Lars

AU - Lund, Thomas Kromann

AU - Kissow, Hannelouise

AU - Backer, Vibeke

AU - Nexø, Ebba

AU - Thim, Lars

AU - Poulsen, Steen Seier

N1 - This article is protected by copyright. All rights reserved.

PY - 2015/7

Y1 - 2015/7

N2 - Objective: Trefoil factor peptides (TFF) are secreted onto mucosal surfaces together with mucins and occur in high concentrations in pulmonary secretions from patients with chronic obstructive pulmonary disease (COPD). In the present study, we aimed to explore the concentrations of the peptides in serum and sputum in patients with COPD.Materials and Methods: Thirty-five individuals were included in the study, including 11 healthy individuals, 13 indivials with asthma and 11 individuals with COPD. TFF1, TFF2 and TFF3 were measured by enzyme-linked immunosorbent assay (ELISA) in sputum induced by hypertonic saline inhalation and in serum. Total protein content in sputum was also determined.Results: In the sputum samples from COPD patients, we observed an eightfold higher concentration of TFF1 and a fivefold higher concentration of TFF3 compared with controls. In the serum samples from COPD patients, we observed three-, three- and twofold higher concentrations of TFF1, TFF2 and TFF3 respectively compared with controls.Conclusions: There is increased secretion of TFF peptides in the lungs of patients with COPD, as well as significant increases in serum levels. This suggests a role for TFF peptides in the pathogenesis of pulmonary diseases with mucus hypersecretion.

AB - Objective: Trefoil factor peptides (TFF) are secreted onto mucosal surfaces together with mucins and occur in high concentrations in pulmonary secretions from patients with chronic obstructive pulmonary disease (COPD). In the present study, we aimed to explore the concentrations of the peptides in serum and sputum in patients with COPD.Materials and Methods: Thirty-five individuals were included in the study, including 11 healthy individuals, 13 indivials with asthma and 11 individuals with COPD. TFF1, TFF2 and TFF3 were measured by enzyme-linked immunosorbent assay (ELISA) in sputum induced by hypertonic saline inhalation and in serum. Total protein content in sputum was also determined.Results: In the sputum samples from COPD patients, we observed an eightfold higher concentration of TFF1 and a fivefold higher concentration of TFF3 compared with controls. In the serum samples from COPD patients, we observed three-, three- and twofold higher concentrations of TFF1, TFF2 and TFF3 respectively compared with controls.Conclusions: There is increased secretion of TFF peptides in the lungs of patients with COPD, as well as significant increases in serum levels. This suggests a role for TFF peptides in the pathogenesis of pulmonary diseases with mucus hypersecretion.

U2 - 10.1111/crj.12146

DO - 10.1111/crj.12146

M3 - Journal article

C2 - 24720774

VL - 9

SP - 322

EP - 329

JO - Clinical Respiratory Journal

JF - Clinical Respiratory Journal

SN - 1752-6981

IS - 3

ER -

ID: 162895069