Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium
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Tobacco and Alcohol in Relation to Male Breast Cancer : An Analysis of the Male Breast Cancer Pooling Project Consortium. / Cook, Michael B; Guénel, Pascal; Gapstur, Susan M; van den Brandt, Piet A; Michels, Karin B; Casagrande, John T; Cooke, Rosie; Van Den Eeden, Stephen K; Ewertz, Marianne; Falk, Roni T; Gaudet, Mia M; Gkiokas, George; Habel, Laurel A; Hsing, Ann W; Johnson, Kenneth; Kolonel, Laurence N; La Vecchia, Carlo; Lynge, Elsebeth; Lubin, Jay H; McCormack, Valerie A; Negri, Eva; Olsson, Håkan; Parisi, Dominick; Petridou, Eleni Th; Riboli, Elio; Sesso, Howard D; Swerdlow, Anthony; Thomas, David B; Willett, Walter C; Brinton, Louise A.
In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 24, No. 3, 03.2015, p. 520-31.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Tobacco and Alcohol in Relation to Male Breast Cancer
T2 - An Analysis of the Male Breast Cancer Pooling Project Consortium
AU - Cook, Michael B
AU - Guénel, Pascal
AU - Gapstur, Susan M
AU - van den Brandt, Piet A
AU - Michels, Karin B
AU - Casagrande, John T
AU - Cooke, Rosie
AU - Van Den Eeden, Stephen K
AU - Ewertz, Marianne
AU - Falk, Roni T
AU - Gaudet, Mia M
AU - Gkiokas, George
AU - Habel, Laurel A
AU - Hsing, Ann W
AU - Johnson, Kenneth
AU - Kolonel, Laurence N
AU - La Vecchia, Carlo
AU - Lynge, Elsebeth
AU - Lubin, Jay H
AU - McCormack, Valerie A
AU - Negri, Eva
AU - Olsson, Håkan
AU - Parisi, Dominick
AU - Petridou, Eleni Th
AU - Riboli, Elio
AU - Sesso, Howard D
AU - Swerdlow, Anthony
AU - Thomas, David B
AU - Willett, Walter C
AU - Brinton, Louise A
N1 - ©2014 American Association for Cancer Research.
PY - 2015/3
Y1 - 2015/3
N2 - BACKGROUND: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined.METHODS: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) ORs and 95% confidence intervals (CI), which were then combined using fixed-effects meta-analysis.RESULTS: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one subanalysis of very high recent alcohol consumption (>60 g/day) was tentatively associated with male breast cancer (ORunexposed referent = 1.29; 95% CI, 0.97-1.71; OR>0-<7 g/day referent = 1.36; 95% CI, 1.04-1.77). Specific alcoholic beverage types were not associated with male breast cancer. Relations were not altered when stratified by age or body mass index.CONCLUSIONS: In this analysis of the Male Breast Cancer Pooling Project, we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer.IMPACT: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer.
AB - BACKGROUND: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined.METHODS: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) ORs and 95% confidence intervals (CI), which were then combined using fixed-effects meta-analysis.RESULTS: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one subanalysis of very high recent alcohol consumption (>60 g/day) was tentatively associated with male breast cancer (ORunexposed referent = 1.29; 95% CI, 0.97-1.71; OR>0-<7 g/day referent = 1.36; 95% CI, 1.04-1.77). Specific alcoholic beverage types were not associated with male breast cancer. Relations were not altered when stratified by age or body mass index.CONCLUSIONS: In this analysis of the Male Breast Cancer Pooling Project, we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer.IMPACT: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer.
U2 - 10.1158/1055-9965.EPI-14-1009
DO - 10.1158/1055-9965.EPI-14-1009
M3 - Journal article
C2 - 25515550
VL - 24
SP - 520
EP - 531
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
SN - 1055-9965
IS - 3
ER -
ID: 135652599